Developmental validation of STRmix (TM), expert software for the interpretation of forensic DNA profiles

Jo-Anne Bright, Duncan Taylor, Catherine McGovern, Stuart Cooper, Laura Russell, Damien Abarno, John Buckleton

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Abstract

    In 2015 the Scientific Working Group on DNA Analysis Methods published the SWGDAM Guidelines for the Validation of Probabilistic Genotyping Systems [1]. STRmix™ is probabilistic genotyping software that employs a continuous model of DNA profile interpretation. This paper describes the developmental validation activities of STRmix™ following the SWGDAM guidelines. It addresses the underlying scientific principles, and the performance of the models with respect to sensitivity, specificity and precision and results of interpretation of casework type samples. This work demonstrates that STRmix™ is suitable for its intended use for the interpretation of single source and mixed DNA profiles.

    Original languageEnglish
    Pages (from-to)226-239
    Number of pages14
    JournalForensic Science International: Genetics
    Volume23
    DOIs
    Publication statusPublished - 2016

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