TY - JOUR
T1 - Device-detected atrial fibrillation in a large remote-monitored cohort
T2 - implications for anticoagulation and need for new pathways of service delivery
AU - O’Shea, Catherine J.
AU - Brooks, Anthony G.
AU - Middeldorp, Melissa E.
AU - Harper, Curtis
AU - Hendriks, Jeroen M.
AU - Russo, Andrea M.
AU - Freeman, James V.
AU - Gopinathannair, Rakesh
AU - Varma, Niraj
AU - Deering, Thomas F.
AU - Campbell, Kevin
AU - Sanders, Prashanthan
PY - 2023/10
Y1 - 2023/10
N2 - Background: Remote monitoring (RM) can facilitate early detection of subclinical and symptomatic atrial fibrillation (AF), providing an opportunity to evaluate the need for stroke prevention therapies. We aimed to characterize the burden of RM AF alerts and its impact on anticoagulation of patients with device-detected AF.Methods: Consecutive patients with a cardiac implantable electronic device, at least one AF episode, undergoing RM were included and assigned an estimated minimum CHA2DS2-VASc score based on age and device type. RM was provided via automated software system, providing rapid alert processing by device specialists and systematic, recurrent prompts for anticoagulation. Results: From 7651 individual, 389,188 AF episodes were identified, 3120 (40.8%) permanent pacemakers, 2260 (29.5%) implantable loop recorders (ILRs), 987 (12.9%) implantable cardioverter defibrillators, 968 (12.7%) cardiac resynchronization therapy (CRT) defibrillators, and 316 (4.1%) CRT pacemakers. ILRs transmitted 48.8% of all AF episodes. At twelve-months, 3404 (44.5%) AF < 6 min, 1367 (17.9%) 6 min–6 h, 1206 (15.8%) 6–24 h, and 1674 (21.9%) ≥ 24 h. A minimum CHA2DS2-VASc score of 2 was assigned to 1704 (63.1%) of the patients with an AF episode of ≥ 6 h, 531 (31.2%) who were not anticoagulated at 12-months, and 1031 (61.6%) patients with an AF episode duration of ≥ 24 h, 290 (28.1%) were not anticoagulated. Conclusions: Despite being intensively managed via RM software system incorporating cues for anticoagulation, a substantial proportion of patients with increased stroke risk remained unanticoagulated after a device-detected AF episode of significant duration. These data highlight the need for improved clinical response pathways and an integrated care approach to RM. Trial registration: Australian New Zealand Clinical Trial Registry: ACTRN12620001232921.
AB - Background: Remote monitoring (RM) can facilitate early detection of subclinical and symptomatic atrial fibrillation (AF), providing an opportunity to evaluate the need for stroke prevention therapies. We aimed to characterize the burden of RM AF alerts and its impact on anticoagulation of patients with device-detected AF.Methods: Consecutive patients with a cardiac implantable electronic device, at least one AF episode, undergoing RM were included and assigned an estimated minimum CHA2DS2-VASc score based on age and device type. RM was provided via automated software system, providing rapid alert processing by device specialists and systematic, recurrent prompts for anticoagulation. Results: From 7651 individual, 389,188 AF episodes were identified, 3120 (40.8%) permanent pacemakers, 2260 (29.5%) implantable loop recorders (ILRs), 987 (12.9%) implantable cardioverter defibrillators, 968 (12.7%) cardiac resynchronization therapy (CRT) defibrillators, and 316 (4.1%) CRT pacemakers. ILRs transmitted 48.8% of all AF episodes. At twelve-months, 3404 (44.5%) AF < 6 min, 1367 (17.9%) 6 min–6 h, 1206 (15.8%) 6–24 h, and 1674 (21.9%) ≥ 24 h. A minimum CHA2DS2-VASc score of 2 was assigned to 1704 (63.1%) of the patients with an AF episode of ≥ 6 h, 531 (31.2%) who were not anticoagulated at 12-months, and 1031 (61.6%) patients with an AF episode duration of ≥ 24 h, 290 (28.1%) were not anticoagulated. Conclusions: Despite being intensively managed via RM software system incorporating cues for anticoagulation, a substantial proportion of patients with increased stroke risk remained unanticoagulated after a device-detected AF episode of significant duration. These data highlight the need for improved clinical response pathways and an integrated care approach to RM. Trial registration: Australian New Zealand Clinical Trial Registry: ACTRN12620001232921.
KW - Anticoagulation
KW - Atrial fibrillation
KW - Cardiac implantable electronic device
KW - Remote monitoring
UR - http://www.scopus.com/inward/record.url?scp=85147367486&partnerID=8YFLogxK
U2 - 10.1007/s10840-023-01481-4
DO - 10.1007/s10840-023-01481-4
M3 - Article
C2 - 36735111
AN - SCOPUS:85147367486
SN - 1383-875X
VL - 66
SP - 1659
EP - 1668
JO - JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
JF - JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
IS - 7
ER -
