Diagnosis of Lung Adenocarcinoma in Resected Specimens: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification

W Travis, Elisabeth Brambila, Masayuki Noguchi, Andrew Nicholson, Kim Geisinger, Yasushi Yatabe, Yuichi Ishikawa, Ignacio Wistuba, Douglas Flieder, Wilbur Franklin, Adi Gazdar, P Hasleton, Douglas Henderson, Keith Kerr, Yukio Nakatani, Iver Petersen, Victor Roggli, Erik Thunnissen, Ming Tsao

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    Abstract

    A new lung adenocarcinoma classification has been published by the International Association for the Study of Lung Cancer, the American Thoracic Society, and the European Respiratory Society. This new classification is needed to provide uniform terminology and diagnostic criteria, most especially for bronchioloalveolar carcinoma. It was developed by an international core panel of experts representing all 3 societies with oncologists/pulmonologists, pathologists, radiologists, molecular biologists, and thoracic surgeons.This summary focuses on the aspects of this classification that address resection specimens. The terms bronchioloalveolar carcinoma and mixed subtype adenocarcinoma are no longer used. For resection specimens, new concepts are introduced, such as adenocarcinoma in situ and minimally invasive adenocarcinoma for small solitary adenocarcinomas with either pure lepidic growth (adenocarcinoma in situ) and predominant lepidic growth with invasion of 5 mm or less (minimally invasive adenocarcinoma), to define the condition of patients who will have 100% or near 100% disease-specific survival, respectively, if they undergo complete lesion resection. Adenocarcinoma in situ and minimally invasive adenocarcinoma are usually nonmucinous, but rarely may be mucinous. Invasive adenocarcinomas are now classified by predominant pattern after using comprehensive histologic subtyping with lepidic (formerly most mixed subtype tumors with nonmucinous bronchioloalveolar carcinoma), acinar, papillary, and solid patterns; micropapillary is added as a new histologic subtype. Variants include invasive mucinous adenocarcinoma (formerly mucinous bronchioloalveolar carcinoma), colloid, fetal, and enteric adenocarcinoma.It is possible that this classification may impact the next revision of the TNM staging classification, with adjustment of the size T factor according to only the invasive component pathologically in adenocarcinomas with lepidic areas.

    Original languageEnglish
    Pages (from-to)685-705
    Number of pages21
    JournalArchives of Pathology and Laboratory Medicine
    Volume137
    Issue number5
    DOIs
    Publication statusPublished - 2013

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    Travis, W., Brambila, E., Noguchi, M., Nicholson, A., Geisinger, K., Yatabe, Y., Ishikawa, Y., Wistuba, I., Flieder, D., Franklin, W., Gazdar, A., Hasleton, P., Henderson, D., Kerr, K., Nakatani, Y., Petersen, I., Roggli, V., Thunnissen, E., & Tsao, M. (2013). Diagnosis of Lung Adenocarcinoma in Resected Specimens: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification. Archives of Pathology and Laboratory Medicine, 137(5), 685-705. https://doi.org/10.5858/arpa.2012-0264-RA