Diagnosis of Prostate Cancer and Prostatitis Using near Infra-Red Fluorescent AgInSe/ZnS Quantum Dots

Vuyelwa Ncapayi, Neethu Ninan, Thabang C. Lebepe, Sundararajan Parani, Aswathy Ravindran Girija, Richard Bright, Krasimir Vasilev, Rodney Maluleke, Ncediwe Tsolekile, Tetsuya Kodama, Oluwatobi S. Oluwafemi

Research output: Contribution to journalArticlepeer-review

Abstract

The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.

Original languageEnglish
Article number12514
Number of pages11
JournalInternational Journal of Molecular Sciences
Volume22
Issue number22
DOIs
Publication statusPublished - 2 Nov 2021
Externally publishedYes

Keywords

  • Bioimaging
  • Gram-negative bacteria
  • Gram-positive bacteria
  • Near infra-red quantum dots
  • Prostate cancer

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