Dietary inflammatory index and the aging kidney in older women: a 10-year prospective cohort study

Nicola P. Bondonno, Lauren C. Blekkenhorst, Anna L. Bird, Joshua R. Lewis, Jonathan M. Hodgson, Nitin Shivappa, James R. Hébert, Richard J. Woodman, Germaine Wong, Deborah A. Kerr, Wai H. Lim, Richard L. Prince

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Purpose: Chronic inflammation plays a role in the pathogenesis of age-related renal disease and the diet can moderate systemic inflammation. The primary objective of this study was to examine the associations between a dietary inflammatory index (DII®) score and renal function, the trajectory of renal function decline, and renal disease-related hospitalizations and/or mortality over 10 years. Methods: The study was conducted in 1422 Western Australian women without prevalent chronic kidney disease and aged ≥ 70 years. Baseline dietary data, obtained from a validated food frequency questionnaire, were used to calculate a DII score for each individual. Results: In this cohort, the mean [range] DII score was 0.19 [− 6.14 to 6.39]. A higher DII score was associated with poorer renal function at baseline and a greater renal function decline over 10 years; after multivariable adjustments, a one-unit higher DII score was associated with a 0.55 mL/min/1.73 m2 lower eGFR at baseline (p = 0.01) and a 0.06 mL/min/1.73 m2 greater annual decline in eGFR over 10 years (p = 0.05). Restricted cubic splines provide evidence of a non-linear association between baseline DII score and risk of a renal disease-related event. Compared to participants in the lowest quintile, those in the highest quintile of DII score were at a higher risk of experiencing a renal disease-related event (adjusted HR 2.06, 95% CI 0.97, 4.37). Conclusion: Recommending an increased consumption of foods with a higher anti-inflammatory potential could form part of a multifaceted approach to reduce the risk of renal disease through diet and lifestyle changes.

Original languageEnglish
Pages (from-to)3201-3211
Number of pages11
JournalEuropean Journal of Nutrition
Issue number7
Publication statusPublished - 1 Oct 2020


  • Chronic kidney disease
  • Dietary inflammatory index
  • Prospective cohort study
  • Renal decline
  • Renal disease


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