Dietary patterns and risk of oesophageal cancers: a population-based case–control study

Torukiri Ibiebele, Maria Celia Hughes, David C. Whiteman, Penelope M. Webb, Adele Green, Nicholas Hayward, David Purdie, Peter Parsons, Mark Smithers, David Gotley, Andrew Clouston, Ian Brown, Charles Mosse, Noel Tait, Chris Bambach, Andrew Biankan, Roy Brancatisano, Max Coleman, Michael Cox, Stephen DeaneGregory Falk, James Gallagher, Mike Hollands, Tom Hugh, David Hunt, John Jorgensen, Christopher Martin, Mark Richardson, Garrett Smith, Ross Smith, David Storey, John Avramovic, John Croese, Justin D'Arcy, Stephen Fairley, John Hansen, John Masson, Les Nathanson, Barry O'Loughlin, Leigh Rutherford, Richard Turner, Morgan Windsor, Justin Bessell, Peter Devitt, Glyn Jamieson, David Watson

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Epidemiological studies investigating the association between dietary intake and oesophageal cancer have mostly focused on nutrients and food groups instead of dietary patterns. We conducted a population-based case-control study, which included 365 oesophageal adenocarcinoma (OAC), 426 oesophagogastric junction adenocarcinoma (OGJAC) and 303 oesophageal squamous cell carcinoma (OSCC) cases, with frequency matched on age, sex and geographical location to 1580 controls. Data on demographic, lifestyle and dietary factors were collected using self-administered questionnaires. We used principal component analysis to derive three dietary patterns: 'meat and fat', 'pasta and pizza' and 'fruit and vegetable', and unconditional logistic regression models to estimate risks of OAC, OGJAC and OSCC associated with quartiles (Q) of dietary pattern scores. A high score on the meat-and-fat pattern was associated with increased risk of all three cancers: multivariable-adjusted OR 2·12 (95 % CI 1·30, 3·46) for OAC; 1·88 (95% CI 1·21, 2·94) for OGJAC; 2·84 (95% CI 1·67, 4·83) for OSCC (P-trend <0·01 for all three cancers). A high score on the pasta-and-pizza pattern was inversely associated with OSCC risk (OR 0·58, 95 % CI 0·36, 0·96, P for trend=0·009); and a high score on the fruit-and-vegetable pattern was associated with a borderline significant decreased risk of OGJAC (OR for Q4 v. Q1 0·66, 95% CI 0·42, 1·04, P=0·07) and significantly decreased risk of OSCC (OR 0·41, 95% CI 0·24, 0·70, P for trend=0·002). High-fat dairy foods appeared to play a dominant role in the association between the meat-and-fat pattern and risk of OAC and OGJAC. Further investigation in prospective studies is needed to confirm these findings.

    Original languageEnglish
    Pages (from-to)1207-1216
    Number of pages10
    JournalBritish Journal of Nutrition
    Volume107
    Issue number8
    DOIs
    Publication statusPublished - Apr 2012

    Keywords

    • dietary patterns
    • oesophageal cancer
    • Case-control studies
    • principal component analysis

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