Dietary Potassium Intake and All-Cause Mortality in Adults Treated with Hemodialysis

Amelie Bernier-Jean, Germaine Wong, Valeria Saglimbene, Marinella Ruospo, Suetonia C. Palmer, Patrizia Natale, Vanessa Garcia-Larsen, David W. Johnson, Marcello Tonelli, Jorgen Hegbrant, Jonathan C. Craig, Armando Teixeira-Pinto, Giovanni F.M. Strippoli

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background and objectives Dietary potassium restriction in people receiving maintenance hemodialysis is standard practice and is recommended in guidelines, despite a lack of evidence.We aimed to assess the association between dietary potassium intake and mortality and whether hyperkalemia mediates this association. Design, setting, participants, & measurements A total of 8043 adults undergoing maintenance hemodialysis in Europe and South America were included in the DIETary intake, death and hospitalization in adults with endstage kidney disease treated with HemoDialysis (DIET-HD) study.We measured baseline potassium intake from the Global Allergy and Asthma European Network food frequency questionnaire and performed time-to-event and mediation analyses. Results The median potassium intake at baseline was 3.5 (interquartile range, 2.5–5.0) g/d. During a median follow-up of 4.0 years (25,890 person-years), we observed 2921 (36%) deaths. After adjusting for baseline characteristics, including cardiac disease and food groups, dietary potassium intake was not associated with allcause mortality (per 1 g/d higher dietary potassium intake: Hazard ratio, 1.00; 95% confidence interval [95% CI], 0.95 to 1.05). A mediation analysis showed no association of potassium intake with mortality, either through or independent of serum potassium (hazard ratio, 1.00; 95% CI, 1.00 to 1.00 and hazard ratio, 1.01; 95% CI, 0.96 to 1.06, respectively). Potassium intake was not significantly associated with serum levels (0.03; 95% CI, 20.01 to 0.07 mEq/L per 1 g/d higher dietary potassium intake) or the prevalence of hyperkalemia ($6.0 mEq/L) at baseline (odds ratio, 1.11; 95% CI, 0.89 to 1.37 per 1 g/d higher dietary potassium intake). Hyperkalemia was associated with cardiovascular death (hazard ratio, 1.23; 95% CI, 1.03 to 1.48). Conclusions Higher dietary intake of potassium is not associated with hyperkalemia or death in patients treated with hemodialysis.

Original languageEnglish
Pages (from-to)1851-1861
Number of pages11
JournalClinical Journal of the American Society of Nephrology
Volume16
Issue number12
DOIs
Publication statusPublished - Dec 2021

Keywords

  • hemodialysis
  • nutrition
  • mortality
  • potassium
  • dietary
  • cohort studies
  • diet

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