TY - JOUR
T1 - Dietary zinc and the control of Streptococcus pneumoniae infection
AU - Eijkelkamp, Bart A.
AU - Morey, Jacqueline R.
AU - Neville, Stephanie L.
AU - Tan, Aimee
AU - Pederick, Victoria G.
AU - Cole, Nerida
AU - Singh, Prashina P.
AU - Ong, Cheryl Lynn Y.
AU - Gonzalez de Vega, Raquel
AU - Clases, David
AU - Cunningham, Bliss A.
AU - Hughes, Catherine E.
AU - Comerford, Iain
AU - Brazel, Erin B.
AU - Whittall, Jonathan J.
AU - Plumptre, Charles D.
AU - McColl, Shaun R.
AU - Paton, James C.
AU - McEwan, Alastair G.
AU - Doble, Philip A.
AU - McDevitt, Christopher A.
N1 - Copyright: © 2019 Eijkelkamp et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/8/22
Y1 - 2019/8/22
N2 - Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc deficiency. We report that dietary zinc levels dictate the outcome of S. pneumoniae infection in a murine model. Dietary zinc restriction impacts murine tissue zinc levels with distribution post-infection altered, and S. pneumoniae virulence and infection enhanced. Although the activation and infiltration of murine phagocytic cells was not affected by zinc restriction, their efficacy of bacterial control was compromised. S. pneumoniae was shown to be highly sensitive to zinc intoxication, with this process impaired in zinc restricted mice and isolated phagocytic cells. Collectively, these data show how dietary zinc deficiency increases sensitivity to S. pneumoniae infection while revealing a role for zinc as a component of host antimicrobial defences.
AB - Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc deficiency. We report that dietary zinc levels dictate the outcome of S. pneumoniae infection in a murine model. Dietary zinc restriction impacts murine tissue zinc levels with distribution post-infection altered, and S. pneumoniae virulence and infection enhanced. Although the activation and infiltration of murine phagocytic cells was not affected by zinc restriction, their efficacy of bacterial control was compromised. S. pneumoniae was shown to be highly sensitive to zinc intoxication, with this process impaired in zinc restricted mice and isolated phagocytic cells. Collectively, these data show how dietary zinc deficiency increases sensitivity to S. pneumoniae infection while revealing a role for zinc as a component of host antimicrobial defences.
KW - zinc deficiency
KW - bacterial infection
KW - zinc supplementation
UR - http://www.scopus.com/inward/record.url?scp=85071415263&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/nhmrc/1080784
UR - http://purl.org/au-research/grants/nhmrc/1122582
UR - http://purl.org/au-research/grants/nhmrc/1071659
UR - http://purl.org/au-research/grants/arc/DP170100036
UR - http://purl.org/au-research/grants/arc/DP190102361
UR - http://purl.org/au-research/grants/arc/DP170102102
UR - http://purl.org/au-research/grants/nhmrc/1142695
UR - http://purl.org/au-research/grants/arc/FT170100006
U2 - 10.1371/journal.ppat.1007957
DO - 10.1371/journal.ppat.1007957
M3 - Article
C2 - 31437249
AN - SCOPUS:85071415263
SN - 1553-7366
VL - 15
JO - PLoS Pathogens
JF - PLoS Pathogens
IS - 8
M1 - e1007957
ER -
