Different mechanisms of Cardiovascular Risk in Men with OSA: The Role of the Arousal Threshold

Sarah Appleton; D Eckert; A Vakulin; Peter Catcheside; D McEvoy; Sean Martin; Gary Wittert; Robert Adams

doi:10.1093/sleep/zsy061.444

Different mechanisms of Cardiovascular Risk in Men with OSA: The Role of the Arousal Threshold

Sarah Appleton, D Eckert, A Vakulin, Peter Catcheside, D McEvoy, Sean Martin, Gary Wittert, Robert Adams

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Obstructive sleep apnea (OSA) has a multifactorial aetiology. Waking up too easily to minor airway narrowing (a low respiratory arousal threshold: ArTH) contributes to OSA pathogenesis in approximately 1/3 of OSA patients. Conversely, others require substantial respiratory stimuli (ventilatory drive) to elicit cortical arousal (high arousal threshold). The extent to which the ArTH phenotype contributes to common clinical consequences of OSA such as blood pressure and glucose control is unknown. Thus, we aimed to determine relationships between the ArTH with blood pressure and glucose control.

Original language	English
Article number	0445
Pages (from-to)	A168-A169
Number of pages	2
Journal	SLEEP
Volume	41
Issue number	S1
DOIs	https://doi.org/10.1093/sleep/zsy061.444
Publication status	Published - Apr 2018
Event	32nd Annual Meeting of the Associated-Professional-Sleep-Societies- LLC (APSS) - Baltimore, United States Duration: 2 Jun 2018 → 6 Jun 2018

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title = "Different mechanisms of Cardiovascular Risk in Men with OSA: The Role of the Arousal Threshold",

abstract = "Obstructive sleep apnea (OSA) has a multifactorial aetiology. Waking up too easily to minor airway narrowing (a low respiratory arousal threshold: ArTH) contributes to OSA pathogenesis in approximately 1/3 of OSA patients. Conversely, others require substantial respiratory stimuli (ventilatory drive) to elicit cortical arousal (high arousal threshold). The extent to which the ArTH phenotype contributes to common clinical consequences of OSA such as blood pressure and glucose control is unknown. Thus, we aimed to determine relationships between the ArTH with blood pressure and glucose control.",

author = "Sarah Appleton and D Eckert and A Vakulin and Peter Catcheside and D McEvoy and Sean Martin and Gary Wittert and Robert Adams",

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T1 - Different mechanisms of Cardiovascular Risk in Men with OSA

T2 - 32nd Annual Meeting of the Associated-Professional-Sleep-Societies- LLC (APSS)

AU - Appleton, Sarah

AU - Eckert, D

AU - Vakulin, A

AU - Catcheside, Peter

AU - McEvoy, D

AU - Martin, Sean

AU - Wittert, Gary

AU - Adams, Robert

PY - 2018/4

Y1 - 2018/4

N2 - Obstructive sleep apnea (OSA) has a multifactorial aetiology. Waking up too easily to minor airway narrowing (a low respiratory arousal threshold: ArTH) contributes to OSA pathogenesis in approximately 1/3 of OSA patients. Conversely, others require substantial respiratory stimuli (ventilatory drive) to elicit cortical arousal (high arousal threshold). The extent to which the ArTH phenotype contributes to common clinical consequences of OSA such as blood pressure and glucose control is unknown. Thus, we aimed to determine relationships between the ArTH with blood pressure and glucose control.

AB - Obstructive sleep apnea (OSA) has a multifactorial aetiology. Waking up too easily to minor airway narrowing (a low respiratory arousal threshold: ArTH) contributes to OSA pathogenesis in approximately 1/3 of OSA patients. Conversely, others require substantial respiratory stimuli (ventilatory drive) to elicit cortical arousal (high arousal threshold). The extent to which the ArTH phenotype contributes to common clinical consequences of OSA such as blood pressure and glucose control is unknown. Thus, we aimed to determine relationships between the ArTH with blood pressure and glucose control.

U2 - 10.1093/sleep/zsy061.444

DO - 10.1093/sleep/zsy061.444

M3 - Meeting Abstract

VL - 41

SP - A168-A169

JO - Sleep

JF - Sleep

SN - 0161-8105

IS - S1

M1 - 0445

Y2 - 2 June 2018 through 6 June 2018

ER -

Different mechanisms of Cardiovascular Risk in Men with OSA: The Role of the Arousal Threshold

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