Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria

Ervi Salwati, Gabriela Minigo, Tonia Woodberry, Kim Piera, Harini de Silva, E Kenangalem, E Tjitra, Ross Coppel, Ric Price, Nicholas Anstey, Magdalena Plebanski

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    5 Citations (Scopus)

    Abstract

    Background. Plasmodium falciparum and Plasmodium vivax are co-endemic in the Asia-Pacific region. Their capacity to induce and sustain diverse T-cell responses underpins protective immunity. We compared T-cell responses to the largely conserved merozoite surface protein-5 (PfMSP5) during acute and convalescent falciparum and vivax malaria. Methods. Lymphoproliferation and IFN-γ secretion to PfMSP5 and purified protein derivate were quantified in adults with falciparum (n = 34), and vivax malaria (n = 12) or asymptomatic residents (n = 10) of Papua, Indonesia. Responses were reassessed 7-28 days following treatment. Results. The frequency of IFN-γ responders to PfMSP5 was similar in acute falciparum (63%) or vivax (67%) malaria. However, significantly more IFN-γ-secreting cells were detectable during vivax compared with falciparum infection. Purified protein derivative responses showed a similarly enhanced pattern. While rapidly lost in vivax patients, PfMSP5-specific responses in falciparum malaria remained to day 28. By contrast, frequency and magnitude of lymphoproliferation to PfMSP5 were similar for falciparum and vivax infections. Conclusion. Cellular PfMSP5-specific responses are most frequent during either acute falciparum or vivax malaria, indicating functional T-cell responses to conserved antigens. Both effector and central memory T-cell functions are increased. Greater IFN-γ responses in acute P. vivax, suggest enhancement of pre-existing effector T-cells during acute vivax infection.

    Original languageEnglish
    Pages (from-to)1192-1199
    Number of pages8
    JournalJournal of Infectious Diseases
    Volume203
    Issue number8
    DOIs
    Publication statusPublished - 15 Apr 2011

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