Differential induction of UDP glucuronosyltransferase activities towards various substrates after polycyclic aromatic hydrocarbon administration to rats

Peter I. Mackenzie, Matti Väisänen, Osmo Hänninen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Administration of the carcinogens, benzo[a]pyrene and 1,2-benzanthracene, increased UDP glucuronosyltransferase activities towards 4-nitrophenol, 3-hydroxybenzo[a]pyrene, 7-hydroxycoumarin and 1-naphthol to a greater extent than did pretreatment with the nonearcinogens, anthracene and phenanthrene. However, the activity towards morphine was preferentially increased by the nonearcinogens. Activities towards testosterone and oestrone were only slightly increased by the four hydrocarbons. The results suggest that even within a single class of inducer various compounds are capable of causing a differential stimulation of UDP glucuronosyltransferase activities towards certain substrates.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalToxicology Letters
Volume12
Issue number4
DOIs
Publication statusPublished - Aug 1982
Externally publishedYes

Fingerprint Dive into the research topics of 'Differential induction of UDP glucuronosyltransferase activities towards various substrates after polycyclic aromatic hydrocarbon administration to rats'. Together they form a unique fingerprint.

  • Cite this