Differentiating Anderson-Fabry Disease from Other Causes of Left Ventricular Hypertrophy: Novel Insights from Left Atrial Strain Imaging

Madiha Saiedi; Liza Thomas; Mark Thomas; Nikola Stoyanov; Kotaro Nochioka; Rebecca Kozor; Geu Ru Hong; Ian Chapman; Rebecca Perry; Joseph B. Selvanayagam

doi:10.1016/j.echo.2025.10.009

Differentiating Anderson-Fabry Disease from Other Causes of Left Ventricular Hypertrophy: Novel Insights from Left Atrial Strain Imaging

Madiha Saiedi
, Liza Thomas
, Mark Thomas
, Nikola Stoyanov
, Kotaro Nochioka
, Rebecca Kozor
, Geu Ru Hong
, Ian Chapman
, Rebecca Perry
, Joseph B. Selvanayagam

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Anderson-Fabry disease (AFD) is a rare X-linked lysosomal storage disorder, characterized by the accumulation of globotriaosylceramide (Gb3) within the myocardium, leading to structural changes of left ventricular hypertrophy (LVH) and myocardial fibrosis.1 Historically, research in AFD has focused on the left ventricle (LV),2,3 but recent studies suggest that Gb3 accumulation also affects the right ventricle (RV) and left atrium (LA).

Original language	English
Pages (from-to)	222-225
Number of pages	4
Journal	Journal of the American Society of Echocardiography
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/j.echo.2025.10.009
Publication status	Published - Feb 2026

Keywords

Anderson-Fabry disease
left ventricular hypertrophy (LVH)
Left Atrial Strain Imaging
X-linked lysosomal storage disorder
globotriaosylceramide (Gb3)
myocardial fibrosis

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10.1016/j.echo.2025.10.009Licence: In Copyright

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Saiedi, M., Thomas, L., Thomas, M., Stoyanov, N., Nochioka, K., Kozor, R., Hong, G. R., Chapman, I., Perry, R., & Selvanayagam, J. B. (2026). Differentiating Anderson-Fabry Disease from Other Causes of Left Ventricular Hypertrophy: Novel Insights from Left Atrial Strain Imaging. Journal of the American Society of Echocardiography, 39(2), 222-225. https://doi.org/10.1016/j.echo.2025.10.009

@article{4b38b9f2e7ba4ea08ab956d48c59d8bd,

title = "Differentiating Anderson-Fabry Disease from Other Causes of Left Ventricular Hypertrophy: Novel Insights from Left Atrial Strain Imaging",

abstract = "Anderson-Fabry disease (AFD) is a rare X-linked lysosomal storage disorder, characterized by the accumulation of globotriaosylceramide (Gb3) within the myocardium, leading to structural changes of left ventricular hypertrophy (LVH) and myocardial fibrosis.1 Historically, research in AFD has focused on the left ventricle (LV),2,3 but recent studies suggest that Gb3 accumulation also affects the right ventricle (RV) and left atrium (LA).",

keywords = "Anderson-Fabry disease, left ventricular hypertrophy (LVH), Left Atrial Strain Imaging, X-linked lysosomal storage disorder, globotriaosylceramide (Gb3), myocardial fibrosis",

author = "Madiha Saiedi and Liza Thomas and Mark Thomas and Nikola Stoyanov and Kotaro Nochioka and Rebecca Kozor and Hong, \{Geu Ru\} and Ian Chapman and Rebecca Perry and Selvanayagam, \{Joseph B.\}",

year = "2026",

month = feb,

doi = "10.1016/j.echo.2025.10.009",

language = "English",

volume = "39",

pages = "222--225",

journal = "Journal of the American Society of Echocardiography",

issn = "0894-7317",

publisher = "Elsevier Inc.",

number = "2",

}

Saiedi, M, Thomas, L, Thomas, M, Stoyanov, N, Nochioka, K, Kozor, R, Hong, GR, Chapman, I, Perry, R & Selvanayagam, JB 2026, 'Differentiating Anderson-Fabry Disease from Other Causes of Left Ventricular Hypertrophy: Novel Insights from Left Atrial Strain Imaging', Journal of the American Society of Echocardiography, vol. 39, no. 2, pp. 222-225. https://doi.org/10.1016/j.echo.2025.10.009

TY - JOUR

T1 - Differentiating Anderson-Fabry Disease from Other Causes of Left Ventricular Hypertrophy

T2 - Novel Insights from Left Atrial Strain Imaging

AU - Saiedi, Madiha

AU - Thomas, Liza

AU - Thomas, Mark

AU - Stoyanov, Nikola

AU - Nochioka, Kotaro

AU - Kozor, Rebecca

AU - Hong, Geu Ru

AU - Chapman, Ian

AU - Perry, Rebecca

AU - Selvanayagam, Joseph B.

PY - 2026/2

Y1 - 2026/2

N2 - Anderson-Fabry disease (AFD) is a rare X-linked lysosomal storage disorder, characterized by the accumulation of globotriaosylceramide (Gb3) within the myocardium, leading to structural changes of left ventricular hypertrophy (LVH) and myocardial fibrosis.1 Historically, research in AFD has focused on the left ventricle (LV),2,3 but recent studies suggest that Gb3 accumulation also affects the right ventricle (RV) and left atrium (LA).

AB - Anderson-Fabry disease (AFD) is a rare X-linked lysosomal storage disorder, characterized by the accumulation of globotriaosylceramide (Gb3) within the myocardium, leading to structural changes of left ventricular hypertrophy (LVH) and myocardial fibrosis.1 Historically, research in AFD has focused on the left ventricle (LV),2,3 but recent studies suggest that Gb3 accumulation also affects the right ventricle (RV) and left atrium (LA).

KW - Anderson-Fabry disease

KW - left ventricular hypertrophy (LVH)

KW - Left Atrial Strain Imaging

KW - X-linked lysosomal storage disorder

KW - globotriaosylceramide (Gb3)

KW - myocardial fibrosis

UR - https://www.scopus.com/pages/publications/105023866930

U2 - 10.1016/j.echo.2025.10.009

DO - 10.1016/j.echo.2025.10.009

M3 - Article

C2 - 41161422

AN - SCOPUS:105023866930

SN - 0894-7317

VL - 39

SP - 222

EP - 225

JO - Journal of the American Society of Echocardiography

JF - Journal of the American Society of Echocardiography

IS - 2

ER -

Differentiating Anderson-Fabry Disease from Other Causes of Left Ventricular Hypertrophy: Novel Insights from Left Atrial Strain Imaging

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Keywords

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