Diminished Piezo2-Dependent Tactile Sensitivity Occurs in Aging Human Gut and Slows Gastrointestinal Transit in Mice

Lauren A. Jones, Byungchang Jin, Alyce M. Martin, Lai Wei, Flinders Gastrointestinal Consortium, Dayan De Fontgalland, Paul Hollington, David Wattchow, Philippa Rabbitt, Luigi Sposato, Nick Spencer, Seungil Ro, Damien J. Keating

Research output: Contribution to journalArticlepeer-review

Abstract

Enterochromaffin (EC) cell-derived serotonin is released in response to gut contraction to increase the frequency of these contractions and enhance gutmotility. Piezo2 is a nonselective cationic ion channel recently identified as an important mechanosensor in mouse EC cells. There are no reports on human EC cell mechanosensing, the role of Piezo2 in this, and its relevance to in vivo gut motility. The data presented here demonstrate thatPiezo2 is expressed in human EC cells where it regulates mechanically evoked serotonin release. We also identify an age-associated decrease in both mechanically evoked serotonin release and Piezo2 expression in EC cells. Our novel in vivo data in mice demonstrate the relevance of these findings as we show that the induced loss of Piezo2 expression specifically in EC cells drastically slows gut motility.
Original languageEnglish
Pages (from-to)1755-1757.e2
Number of pages5
JournalGastroenterology
Volume162
Issue number6
DOIs
Publication statusPublished - May 2022

Keywords

  • enterochromaffin cell
  • gut contraction
  • Piezo2-Dependent tactile sensitivity
  • aging human gut
  • gut motility
  • EC cell
  • mice

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