Diminished Piezo2-Dependent Tactile Sensitivity Occurs in Aging Human Gut and Slows Gastrointestinal Transit in Mice

Lauren A. Jones; Byungchang Jin; Alyce M. Martin; Lai Wei; Flinders Gastrointestinal Consortium; Dayan De Fontgalland; Paul Hollington; David Wattchow; Philippa Rabbitt; Luigi Sposato; Nick Spencer; Seungil Ro; Damien J. Keating

doi:10.1053/j.gastro.2022.01.043

Diminished Piezo2-Dependent Tactile Sensitivity Occurs in Aging Human Gut and Slows Gastrointestinal Transit in Mice

Lauren A. Jones, Byungchang Jin, Alyce M. Martin, Lai Wei, Flinders Gastrointestinal Consortium, Dayan De Fontgalland, Paul Hollington, David Wattchow, Philippa Rabbitt, Luigi Sposato, Nick Spencer, Seungil Ro, Damien J. Keating

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Enterochromaffin (EC) cell-derived serotonin is released in response to gut contraction to increase the frequency of these contractions and enhance gutmotility. Piezo2 is a nonselective cationic ion channel recently identified as an important mechanosensor in mouse EC cells. There are no reports on human EC cell mechanosensing, the role of Piezo2 in this, and its relevance to in vivo gut motility. The data presented here demonstrate thatPiezo2 is expressed in human EC cells where it regulates mechanically evoked serotonin release. We also identify an age-associated decrease in both mechanically evoked serotonin release and Piezo2 expression in EC cells. Our novel in vivo data in mice demonstrate the relevance of these findings as we show that the induced loss of Piezo2 expression specifically in EC cells drastically slows gut motility.

Original language	English
Pages (from-to)	1755-1757.e2
Number of pages	5
Journal	Gastroenterology
Volume	162
Issue number	6
DOIs	https://doi.org/10.1053/j.gastro.2022.01.043
Publication status	Published - May 2022

Keywords

enterochromaffin cell
gut contraction
Piezo2-Dependent tactile sensitivity
aging human gut
gut motility
EC cell
mice

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Jones, L. A., Jin, B., Martin, A. M., Wei, L., Flinders Gastrointestinal Consortium, De Fontgalland, D., Hollington, P., Wattchow, D., Rabbitt, P., Sposato, L., Spencer, N., Ro, S., & Keating, D. J. (2022). Diminished Piezo2-Dependent Tactile Sensitivity Occurs in Aging Human Gut and Slows Gastrointestinal Transit in Mice. Gastroenterology, 162(6), 1755-1757.e2. https://doi.org/10.1053/j.gastro.2022.01.043

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title = "Diminished Piezo2-Dependent Tactile Sensitivity Occurs in Aging Human Gut and Slows Gastrointestinal Transit in Mice",

abstract = "Enterochromaffin (EC) cell-derived serotonin is released in response to gut contraction to increase the frequency of these contractions and enhance gutmotility. Piezo2 is a nonselective cationic ion channel recently identified as an important mechanosensor in mouse EC cells. There are no reports on human EC cell mechanosensing, the role of Piezo2 in this, and its relevance to in vivo gut motility. The data presented here demonstrate thatPiezo2 is expressed in human EC cells where it regulates mechanically evoked serotonin release. We also identify an age-associated decrease in both mechanically evoked serotonin release and Piezo2 expression in EC cells. Our novel in vivo data in mice demonstrate the relevance of these findings as we show that the induced loss of Piezo2 expression specifically in EC cells drastically slows gut motility.",

keywords = "enterochromaffin cell, gut contraction, Piezo2-Dependent tactile sensitivity, aging human gut, gut motility, EC cell, mice",

author = "Jones, {Lauren A.} and Byungchang Jin and Martin, {Alyce M.} and Lai Wei and {Flinders Gastrointestinal Consortium} and {De Fontgalland}, Dayan and Paul Hollington and David Wattchow and Philippa Rabbitt and Luigi Sposato and Nick Spencer and Seungil Ro and Keating, {Damien J.}",

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doi = "10.1053/j.gastro.2022.01.043",

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Jones, LA, Jin, B, Martin, AM, Wei, L, Flinders Gastrointestinal Consortium, De Fontgalland, D, Hollington, P, Wattchow, D, Rabbitt, P, Sposato, L, Spencer, N, Ro, S & Keating, DJ 2022, 'Diminished Piezo2-Dependent Tactile Sensitivity Occurs in Aging Human Gut and Slows Gastrointestinal Transit in Mice', Gastroenterology, vol. 162, no. 6, pp. 1755-1757.e2. https://doi.org/10.1053/j.gastro.2022.01.043

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AU - Jones, Lauren A.

AU - Jin, Byungchang

AU - Martin, Alyce M.

AU - Wei, Lai

AU - Flinders Gastrointestinal Consortium

AU - De Fontgalland, Dayan

AU - Hollington, Paul

AU - Wattchow, David

AU - Rabbitt, Philippa

AU - Sposato, Luigi

AU - Spencer, Nick

AU - Ro, Seungil

AU - Keating, Damien J.

PY - 2022/5

Y1 - 2022/5

N2 - Enterochromaffin (EC) cell-derived serotonin is released in response to gut contraction to increase the frequency of these contractions and enhance gutmotility. Piezo2 is a nonselective cationic ion channel recently identified as an important mechanosensor in mouse EC cells. There are no reports on human EC cell mechanosensing, the role of Piezo2 in this, and its relevance to in vivo gut motility. The data presented here demonstrate thatPiezo2 is expressed in human EC cells where it regulates mechanically evoked serotonin release. We also identify an age-associated decrease in both mechanically evoked serotonin release and Piezo2 expression in EC cells. Our novel in vivo data in mice demonstrate the relevance of these findings as we show that the induced loss of Piezo2 expression specifically in EC cells drastically slows gut motility.

AB - Enterochromaffin (EC) cell-derived serotonin is released in response to gut contraction to increase the frequency of these contractions and enhance gutmotility. Piezo2 is a nonselective cationic ion channel recently identified as an important mechanosensor in mouse EC cells. There are no reports on human EC cell mechanosensing, the role of Piezo2 in this, and its relevance to in vivo gut motility. The data presented here demonstrate thatPiezo2 is expressed in human EC cells where it regulates mechanically evoked serotonin release. We also identify an age-associated decrease in both mechanically evoked serotonin release and Piezo2 expression in EC cells. Our novel in vivo data in mice demonstrate the relevance of these findings as we show that the induced loss of Piezo2 expression specifically in EC cells drastically slows gut motility.

KW - enterochromaffin cell

KW - gut contraction

KW - Piezo2-Dependent tactile sensitivity

KW - aging human gut

KW - gut motility

KW - EC cell

KW - mice

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Diminished Piezo2-Dependent Tactile Sensitivity Occurs in Aging Human Gut and Slows Gastrointestinal Transit in Mice

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