Dipping your feet in the water: Podocytes in urine

R Elkhatim, Jordan Li, Tuck Yong, Jonathan Gleadle

    Research output: Contribution to journalReview article

    8 Citations (Scopus)

    Abstract

    Podocyte injury and loss plays an important role in the pathogenesis and progression of many kidney diseases. Studies have shown that podocyte-related markers and products can be detected in the urine of patients with glomerular diseases such as focal segmental glomerulosclerosis, IgA nephropathy, lupus nephritis, diabetic nephropathy and pre-eclampsia. Therefore, detecting the loss of podocytes in the urine provides a useful noninvasive technique of gathering information about the disease type and/or activity of glomerular diseases. Currently, urine podocyte-related protein markers, mRNA, microRNA and exosomes have been used with varying degrees of success to study glomerular diseases. The determination of urinary podocyte loss may become an important noninvasive tool in the evaluation of glomerular diseases.

    Original languageEnglish
    Pages (from-to)423-437
    Number of pages15
    JournalExpert Review of Molecular Diagnostics
    Volume14
    Issue number4
    DOIs
    Publication statusPublished - 2014

    Keywords

    • exosome
    • glomerular diseases
    • kidney disease
    • miRNA
    • nephrotic syndrome
    • podocyte
    • podocyturia

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