Direct oral anticoagulants for venous thromboembolism prophylaxis in orthopaedic trauma: a clear first choice?

Ameya Bhanushali; Bhuvanesh Ravichandran; Brandon Stretton; Joshua G. Kovoor; Stephen Bacchi; Joseph N. Hewitt; Christopher D. Ovenden; Aashray K. Gupta; Ruurd L. Jaarsma; Guy J. Maddern

doi:10.1111/ans.18305

Direct oral anticoagulants for venous thromboembolism prophylaxis in orthopaedic trauma: a clear first choice?

Ameya Bhanushali, Bhuvanesh Ravichandran, Brandon Stretton, Joshua G. Kovoor, Stephen Bacchi, Joseph N. Hewitt, Christopher D. Ovenden, Aashray K. Gupta, Ruurd L. Jaarsma, Guy J. Maddern

College of Medicine and Public Health

Research output: Contribution to journal › Comment/debate

2 Citations (Scopus)

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Abstract

Prevention of venous thromboembolism (VTEp) is an integral part in the care of orthopaedic patients. VTE the leading cause of preventable mortality in hospital and orthopaedic surgery confers particularly high-risk. VTE currently complicates 2%–7% of all orthopaedic surgery. Symptomatic VTE results in reduced quality of life and causes mortality in 6%–12% of cases. VTE may increase length of stay (LOS) in hospital and confers large economic costs.

Biological rationale supports the efficacy of direct oral anticoagulants (DOACs) for VTEp in orthopaedic surgery. Orthopaedic surgery accentuates all aspects of Virchow's Triad due to trauma-induced thromboplastin upregulation, intraoperative torniquet use, immobilization, bed rest and polymethylmethacrylate cement...

Original language	English
Pages (from-to)	815-816
Number of pages	2
Journal	ANZ Journal of Surgery
Volume	93
Issue number	4
Early online date	2 Feb 2023
DOIs	https://doi.org/10.1111/ans.18305
Publication status	Published - Apr 2023

Keywords

venous thromboembolism (VTEp)
anticoagulants
orthopaedic patients

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10.1111/ans.18305Licence: CC BY-NC-ND

Final published versionFinal published version, 224 KBLicence: CC BY-NC-ND

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@article{f012c6789514487bac959a2c97a3dbf9,

title = "Direct oral anticoagulants for venous thromboembolism prophylaxis in orthopaedic trauma: a clear first choice?",

abstract = "Prevention of venous thromboembolism (VTEp) is an integral part in the care of orthopaedic patients. VTE the leading cause of preventable mortality in hospital and orthopaedic surgery confers particularly high-risk. VTE currently complicates 2%–7% of all orthopaedic surgery. Symptomatic VTE results in reduced quality of life and causes mortality in 6%–12% of cases. VTE may increase length of stay (LOS) in hospital and confers large economic costs.Biological rationale supports the efficacy of direct oral anticoagulants (DOACs) for VTEp in orthopaedic surgery. Orthopaedic surgery accentuates all aspects of Virchow's Triad due to trauma-induced thromboplastin upregulation, intraoperative torniquet use, immobilization, bed rest and polymethylmethacrylate cement...",

keywords = "venous thromboembolism (VTEp), anticoagulants, orthopaedic patients",

author = "Ameya Bhanushali and Bhuvanesh Ravichandran and Brandon Stretton and Kovoor, {Joshua G.} and Stephen Bacchi and Hewitt, {Joseph N.} and Ovenden, {Christopher D.} and Gupta, {Aashray K.} and Jaarsma, {Ruurd L.} and Maddern, {Guy J.}",

year = "2023",

month = apr,

doi = "10.1111/ans.18305",

language = "English",

volume = "93",

pages = "815--816",

journal = "ANZ Journal of Surgery",

issn = "1445-1433",

publisher = "John Wiley & Sons, Inc",

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TY - JOUR

T1 - Direct oral anticoagulants for venous thromboembolism prophylaxis in orthopaedic trauma

T2 - a clear first choice?

AU - Bhanushali, Ameya

AU - Ravichandran, Bhuvanesh

AU - Stretton, Brandon

AU - Kovoor, Joshua G.

AU - Bacchi, Stephen

AU - Hewitt, Joseph N.

AU - Ovenden, Christopher D.

AU - Gupta, Aashray K.

AU - Jaarsma, Ruurd L.

AU - Maddern, Guy J.

PY - 2023/4

Y1 - 2023/4

N2 - Prevention of venous thromboembolism (VTEp) is an integral part in the care of orthopaedic patients. VTE the leading cause of preventable mortality in hospital and orthopaedic surgery confers particularly high-risk. VTE currently complicates 2%–7% of all orthopaedic surgery. Symptomatic VTE results in reduced quality of life and causes mortality in 6%–12% of cases. VTE may increase length of stay (LOS) in hospital and confers large economic costs.Biological rationale supports the efficacy of direct oral anticoagulants (DOACs) for VTEp in orthopaedic surgery. Orthopaedic surgery accentuates all aspects of Virchow's Triad due to trauma-induced thromboplastin upregulation, intraoperative torniquet use, immobilization, bed rest and polymethylmethacrylate cement...

AB - Prevention of venous thromboembolism (VTEp) is an integral part in the care of orthopaedic patients. VTE the leading cause of preventable mortality in hospital and orthopaedic surgery confers particularly high-risk. VTE currently complicates 2%–7% of all orthopaedic surgery. Symptomatic VTE results in reduced quality of life and causes mortality in 6%–12% of cases. VTE may increase length of stay (LOS) in hospital and confers large economic costs.Biological rationale supports the efficacy of direct oral anticoagulants (DOACs) for VTEp in orthopaedic surgery. Orthopaedic surgery accentuates all aspects of Virchow's Triad due to trauma-induced thromboplastin upregulation, intraoperative torniquet use, immobilization, bed rest and polymethylmethacrylate cement...

KW - venous thromboembolism (VTEp)

KW - anticoagulants

KW - orthopaedic patients

UR - http://www.scopus.com/inward/record.url?scp=85147176602&partnerID=8YFLogxK

U2 - 10.1111/ans.18305

DO - 10.1111/ans.18305

M3 - Comment/debate

AN - SCOPUS:85147176602

SN - 1445-1433

VL - 93

SP - 815

EP - 816

JO - ANZ Journal of Surgery

JF - ANZ Journal of Surgery

IS - 4

ER -

Direct oral anticoagulants for venous thromboembolism prophylaxis in orthopaedic trauma: a clear first choice?

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Keywords

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