Direct oral anticoagulants for venous thromboembolism prophylaxis in orthopaedic trauma: a clear first choice?

Ameya Bhanushali, Bhuvanesh Ravichandran, Brandon Stretton, Joshua G. Kovoor, Stephen Bacchi, Joseph N. Hewitt, Christopher D. Ovenden, Aashray K. Gupta, Ruurd L. Jaarsma, Guy J. Maddern

Research output: Contribution to journalComment/debate

1 Citation (Scopus)
38 Downloads (Pure)

Abstract

Prevention of venous thromboembolism (VTEp) is an integral part in the care of orthopaedic patients. VTE the leading cause of preventable mortality in hospital and orthopaedic surgery confers particularly high-risk. VTE currently complicates 2%–7% of all orthopaedic surgery. Symptomatic VTE results in reduced quality of life and causes mortality in 6%–12% of cases. VTE may increase length of stay (LOS) in hospital and confers large economic costs.

Biological rationale supports the efficacy of direct oral anticoagulants (DOACs) for VTEp in orthopaedic surgery. Orthopaedic surgery accentuates all aspects of Virchow's Triad due to trauma-induced thromboplastin upregulation, intraoperative torniquet use, immobilization, bed rest and polymethylmethacrylate cement...
Original languageEnglish
Pages (from-to)815-816
Number of pages2
JournalANZ Journal of Surgery
Volume93
Issue number4
Early online date2 Feb 2023
DOIs
Publication statusPublished - Apr 2023

Keywords

  • venous thromboembolism (VTEp)
  • anticoagulants
  • orthopaedic patients

Fingerprint

Dive into the research topics of 'Direct oral anticoagulants for venous thromboembolism prophylaxis in orthopaedic trauma: a clear first choice?'. Together they form a unique fingerprint.

Cite this