TY - JOUR
T1 - Direct radioimmunoassay of human plasma atrial natriuretic peptide in various normal and pathophysiological states
T2 - Increase in renal and cardiac failure during exercise
AU - Morris, M.
AU - Cain, M.
AU - Russell, A.
AU - Elliott, J.
AU - Chalmers, J.
PY - 1987
Y1 - 1987
N2 - We have used a sensitive direct radioimmunoassay to study the effects of exercise on plasma atrial natriuretic peptide (ANP) concentrations in man. Plasma ANP concentration increased three-fold in sixteen patients undergoing bicycle ergometer electrocardiographic tests for the investigation of chest pain. Resting ANP concentrations were higher in those patients in whom there was more evidence of heart disease, such as a positive exercise test, treatment with a beta blocker or history of myocardial infarction, although exercise resulted in increased ANP in both groups. We also confirm the increased plasma ANP concentration observed in patients with congestive cardiac failure and renal failure. In nine patients with renal failure routine haemodialysis was accompanied by a 30 per cent reduction in plasma ANP concentration. Plasma ANP concentrations were similar in treated hypertensive patients, untreated borderline hypertensive patients and normotensive subjects.
AB - We have used a sensitive direct radioimmunoassay to study the effects of exercise on plasma atrial natriuretic peptide (ANP) concentrations in man. Plasma ANP concentration increased three-fold in sixteen patients undergoing bicycle ergometer electrocardiographic tests for the investigation of chest pain. Resting ANP concentrations were higher in those patients in whom there was more evidence of heart disease, such as a positive exercise test, treatment with a beta blocker or history of myocardial infarction, although exercise resulted in increased ANP in both groups. We also confirm the increased plasma ANP concentration observed in patients with congestive cardiac failure and renal failure. In nine patients with renal failure routine haemodialysis was accompanied by a 30 per cent reduction in plasma ANP concentration. Plasma ANP concentrations were similar in treated hypertensive patients, untreated borderline hypertensive patients and normotensive subjects.
KW - Atrial natriuretic peptide
KW - Cardiac failure
KW - Exercise
KW - Hypertension
KW - Radioimmunoassay
KW - Renal failure
UR - http://www.scopus.com/inward/record.url?scp=0023222616&partnerID=8YFLogxK
U2 - 10.3109/10641968709161445
DO - 10.3109/10641968709161445
M3 - Article
C2 - 2957125
AN - SCOPUS:0023222616
VL - A9
SP - 703
EP - 718
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
SN - 1064-1963
IS - 4
ER -