Direct radioimmunoassay of human plasma atrial natriuretic peptide in various normal and pathophysiological states: Increase in renal and cardiac failure during exercise

M. Morris, M. Cain, A. Russell, J. Elliott, J. Chalmers

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have used a sensitive direct radioimmunoassay to study the effects of exercise on plasma atrial natriuretic peptide (ANP) concentrations in man. Plasma ANP concentration increased three-fold in sixteen patients undergoing bicycle ergometer electrocardiographic tests for the investigation of chest pain. Resting ANP concentrations were higher in those patients in whom there was more evidence of heart disease, such as a positive exercise test, treatment with a beta blocker or history of myocardial infarction, although exercise resulted in increased ANP in both groups. We also confirm the increased plasma ANP concentration observed in patients with congestive cardiac failure and renal failure. In nine patients with renal failure routine haemodialysis was accompanied by a 30 per cent reduction in plasma ANP concentration. Plasma ANP concentrations were similar in treated hypertensive patients, untreated borderline hypertensive patients and normotensive subjects.

Original languageEnglish
Pages (from-to)703-718
Number of pages16
JournalClinical and Experimental Hypertension
VolumeA9
Issue number4
DOIs
Publication statusPublished - 1987
Externally publishedYes

Keywords

  • Atrial natriuretic peptide
  • Cardiac failure
  • Exercise
  • Hypertension
  • Radioimmunoassay
  • Renal failure

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