Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation

Adam Celiz, James Smith, Asha Patel, Andrew Hook, Divya Rajamohan, Vinoj George, Luke Flatt, Minal Patel, Vidana Epa, Taranjit Singh, Robert Langer, Daniel Anderson, Nicholas Allen, David Hay, David Alan Winkler, David Barrett, Martin Davies, Lorraine Young, Chris Denning, Morgan Alexander

    Research output: Contribution to journalArticle

    49 Citations (Scopus)

    Abstract

    A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.

    Original languageEnglish
    Pages (from-to)4006-4012
    Number of pages7
    JournalAdvanced Materials
    Volume27
    Issue number27
    DOIs
    Publication statusPublished - 2015

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  • Cite this

    Celiz, A., Smith, J., Patel, A., Hook, A., Rajamohan, D., George, V., Flatt, L., Patel, M., Epa, V., Singh, T., Langer, R., Anderson, D., Allen, N., Hay, D., Winkler, D. A., Barrett, D., Davies, M., Young, L., Denning, C., & Alexander, M. (2015). Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation. Advanced Materials, 27(27), 4006-4012. https://doi.org/10.1002/adma.201501351