Discrepancy in chloride measurement with decreasing bicarbonate concentrations

Shailesh Bihari, Steven Galluccio

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)


    Background: Accurate chloride measurement is important in critically ill patients. Methods: Chloride concentration measured simultaneously between the central laboratory (indirect ion-selective electrode) and blood gas analysis (direct ion-selective electrode) were compared. Results: We report a discrepancy with chloride measurement between the central laboratory and blood gas analysis at low bicarbonate levels. Conclusions: Caution should be applied while interpreting the chloride concentration when indirect ion-selective electrode methodology is used, especially in the setting of low serum bicarbonate levels.

    Original languageEnglish
    Pages (from-to)1563-1565
    Number of pages3
    JournalClinical Laboratory
    Issue number8
    Publication statusPublished - 2019


    • Bicarbonate
    • Chloride
    • Ion-selective electrode


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