TY - JOUR
T1 - Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia
AU - Przybyla, Magdalena
AU - Stevens, Claire H.
AU - van der Hoven, Julia
AU - Harasta, Anne
AU - Bi, Mian
AU - Ittner, Arne
AU - van Hummel, Annika
AU - Hodges, John R.
AU - Piguet, Olivier
AU - Karl, Tim
AU - Kassiou, Michael
AU - Housley, Gary D.
AU - Ke, Yazi D.
AU - Ittner, Lars M.
AU - Eersel, Janet van
PY - 2016/9/19
Y1 - 2016/9/19
N2 - Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.
AB - Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.
KW - Behavior
KW - Frontotemporal dementia
KW - Tau
KW - Transgenic mouse model
UR - http://www.scopus.com/inward/record.url?scp=84981314125&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1037746
UR - http://purl.org/au-research/grants/NHMRC/1020562
UR - http://purl.org/au-research/grants/NHMRC/1069173
UR - http://purl.org/au-research/grants/ARC/DP130102027
UR - http://purl.org/au-research/grants/ARC/CE11000102
U2 - 10.1016/j.neulet.2016.08.007
DO - 10.1016/j.neulet.2016.08.007
M3 - Article
C2 - 27521751
AN - SCOPUS:84981314125
VL - 631
SP - 24
EP - 29
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
ER -