Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia

Magdalena Przybyla; Claire H. Stevens; Julia van der Hoven; Anne Harasta; Mian Bi; Arne Ittner; Annika van Hummel; John R. Hodges; Olivier Piguet; Tim Karl; Michael Kassiou; Gary D. Housley; Yazi D. Ke; Lars M. Ittner; Janet van Eersel

doi:10.1016/j.neulet.2016.08.007

Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia

Magdalena Przybyla, Claire H. Stevens, Julia van der Hoven, Anne Harasta, Mian Bi, Arne Ittner, Annika van Hummel, John R. Hodges, Olivier Piguet, Tim Karl, Michael Kassiou, Gary D. Housley, Yazi D. Ke, Lars M. Ittner, Janet van Eersel

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33 Citations (Scopus)

Abstract

Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.

Original language	English
Pages (from-to)	24-29
Number of pages	6
Journal	Neuroscience letters
Volume	631
DOIs	https://doi.org/10.1016/j.neulet.2016.08.007
Publication status	Published - 19 Sept 2016
Externally published	Yes

Keywords

Behavior
Frontotemporal dementia
Tau
Transgenic mouse model

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Przybyla, M., Stevens, C. H., van der Hoven, J., Harasta, A., Bi, M., Ittner, A., van Hummel, A., Hodges, J. R., Piguet, O., Karl, T., Kassiou, M., Housley, G. D., Ke, Y. D., Ittner, L. M., & Eersel, J. V. (2016). Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia. Neuroscience letters, 631, 24-29. https://doi.org/10.1016/j.neulet.2016.08.007

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title = "Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia",

abstract = "Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.",

keywords = "Behavior, Frontotemporal dementia, Tau, Transgenic mouse model",

author = "Magdalena Przybyla and Stevens, {Claire H.} and {van der Hoven}, Julia and Anne Harasta and Mian Bi and Arne Ittner and {van Hummel}, Annika and Hodges, {John R.} and Olivier Piguet and Tim Karl and Michael Kassiou and Housley, {Gary D.} and Ke, {Yazi D.} and Ittner, {Lars M.} and Eersel, {Janet van}",

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Przybyla, M, Stevens, CH, van der Hoven, J, Harasta, A, Bi, M, Ittner, A, van Hummel, A, Hodges, JR, Piguet, O, Karl, T, Kassiou, M, Housley, GD, Ke, YD, Ittner, LM & Eersel, JV 2016, 'Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia', Neuroscience letters, vol. 631, pp. 24-29. https://doi.org/10.1016/j.neulet.2016.08.007

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T1 - Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia

AU - Przybyla, Magdalena

AU - Stevens, Claire H.

AU - van der Hoven, Julia

AU - Harasta, Anne

AU - Bi, Mian

AU - Ittner, Arne

AU - van Hummel, Annika

AU - Hodges, John R.

AU - Piguet, Olivier

AU - Karl, Tim

AU - Kassiou, Michael

AU - Housley, Gary D.

AU - Ke, Yazi D.

AU - Ittner, Lars M.

AU - Eersel, Janet van

PY - 2016/9/19

Y1 - 2016/9/19

N2 - Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.

AB - Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.

KW - Behavior

KW - Frontotemporal dementia

KW - Tau

KW - Transgenic mouse model

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ER -

Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia

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Keywords

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