TY - JOUR
T1 - Disorder specificity despite comorbidity: Resting EEG alpha asymmetry in major depressive disorder and post-traumatic stress disorder
AU - Kemp, Andrew
AU - Griffiths, K
AU - Felmingham, Kim
AU - Shankman, Stewart
AU - Drinkenburg, Wilhelmus
AU - Arns, Martijn
AU - Clark, Christopher
AU - Bryant, Richard
PY - 2010/10
Y1 - 2010/10
N2 - The approach-withdrawal and valence-arousal models highlight that specific brain laterality profiles may distinguish depression and anxiety. However, studies remain to be conducted in multiple clinical populations that directly test the diagnostic specificity of these hypotheses. The current study compared electroencephalographic data under resting state, eyes closed conditions in patients with major depressive disorder (MDD) (N= 15) and post-traumatic stress disorder (PTSD) (N= 14) relative to healthy controls (N= 15) to examine the specificity of brain laterality in these disorders. Key findings included (1) reduced left-frontal activity in MDD, (2) a positive correlation between PTSD severity and right-frontal lateralisation, (3) greater activity in PTSD patients relative to MDD within the right-parietotemporal region, and (4) globally increased alpha power in MDD. Findings partially support the diagnostic applicability of the theoretical frameworks. Future studies may benefit from examining task-driven differences between groups.
AB - The approach-withdrawal and valence-arousal models highlight that specific brain laterality profiles may distinguish depression and anxiety. However, studies remain to be conducted in multiple clinical populations that directly test the diagnostic specificity of these hypotheses. The current study compared electroencephalographic data under resting state, eyes closed conditions in patients with major depressive disorder (MDD) (N= 15) and post-traumatic stress disorder (PTSD) (N= 14) relative to healthy controls (N= 15) to examine the specificity of brain laterality in these disorders. Key findings included (1) reduced left-frontal activity in MDD, (2) a positive correlation between PTSD severity and right-frontal lateralisation, (3) greater activity in PTSD patients relative to MDD within the right-parietotemporal region, and (4) globally increased alpha power in MDD. Findings partially support the diagnostic applicability of the theoretical frameworks. Future studies may benefit from examining task-driven differences between groups.
KW - Alpha asymmetry
KW - Brain Resource International Database
KW - BRAINnet
KW - Depression
KW - EEG
KW - Electroencephalography
KW - MDD
KW - Post-traumatic stress disorder
KW - PTSD
KW - Resting state
UR - http://www.scopus.com/inward/record.url?scp=77956769764&partnerID=8YFLogxK
U2 - 10.1016/j.biopsycho.2010.08.001
DO - 10.1016/j.biopsycho.2010.08.001
M3 - Article
VL - 85
SP - 350
EP - 354
JO - Biological Psychology
JF - Biological Psychology
SN - 0301-0511
IS - 2
ER -