Disorder specificity despite comorbidity: Resting EEG alpha asymmetry in major depressive disorder and post-traumatic stress disorder

Andrew Kemp, K Griffiths, Kim Felmingham, Stewart Shankman, Wilhelmus Drinkenburg, Martijn Arns, Christopher Clark, Richard Bryant

    Research output: Contribution to journalArticle

    95 Citations (Scopus)

    Abstract

    The approach-withdrawal and valence-arousal models highlight that specific brain laterality profiles may distinguish depression and anxiety. However, studies remain to be conducted in multiple clinical populations that directly test the diagnostic specificity of these hypotheses. The current study compared electroencephalographic data under resting state, eyes closed conditions in patients with major depressive disorder (MDD) (N= 15) and post-traumatic stress disorder (PTSD) (N= 14) relative to healthy controls (N= 15) to examine the specificity of brain laterality in these disorders. Key findings included (1) reduced left-frontal activity in MDD, (2) a positive correlation between PTSD severity and right-frontal lateralisation, (3) greater activity in PTSD patients relative to MDD within the right-parietotemporal region, and (4) globally increased alpha power in MDD. Findings partially support the diagnostic applicability of the theoretical frameworks. Future studies may benefit from examining task-driven differences between groups.

    Original languageEnglish
    Pages (from-to)350-354
    Number of pages5
    JournalBiological Psychology
    Volume85
    Issue number2
    DOIs
    Publication statusPublished - Oct 2010

    Keywords

    • Alpha asymmetry
    • Brain Resource International Database
    • BRAINnet
    • Depression
    • EEG
    • Electroencephalography
    • MDD
    • Post-traumatic stress disorder
    • PTSD
    • Resting state

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  • Cite this

    Kemp, A., Griffiths, K., Felmingham, K., Shankman, S., Drinkenburg, W., Arns, M., Clark, C., & Bryant, R. (2010). Disorder specificity despite comorbidity: Resting EEG alpha asymmetry in major depressive disorder and post-traumatic stress disorder. Biological Psychology, 85(2), 350-354. https://doi.org/10.1016/j.biopsycho.2010.08.001