DNA: Hair Analysis

Adrian Linacre, Renée Ottens

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Hairs are encountered commonly in a forensic investigation and can be a source of DNA. The amount of DNA within a single hair is often less than the optimal amount required for nuclear DNA markers. Most of the DNA is within a root sheath with trace amounts of mitochondrial DNA in the shaft. Nuclear DNA testing targets highly repetitive DNA regions called microsatellites. The quantity of starting template required for nuclear DNA profiling is 1. ng, which may be present in the root sheath but not within the hair shaft. Mitochondrial loci are targeted on hair shafts due to their greater copy number.

Original languageEnglish
Title of host publicationEncyclopedia of Forensic and Legal Medicine
EditorsJason Payne-James, Roger W. Byard
PublisherElsevier
Pages337-342 (volume 2)
Number of pages6
Edition2nd
ISBN (Electronic)9780128000557
ISBN (Print)9780128000342
DOIs
Publication statusPublished - 2016

Keywords

  • Allele
  • Anagen
  • Animal testing
  • Catagen
  • Cortex
  • Direct PCR
  • Forensic science
  • Hair
  • SA
  • Medulla
  • Mitochondrial DNA
  • PCR
  • STR typing
  • Telogen
  • Hypervariable region

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