Do pressor neurons in the ventrolateral medulla release amines and neuropeptides?

J. Chalmers, V. Kapoor, E. Mills, J. Minson, M. Morris, P. Pilowsky, M. West

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Activation of neurons arising in the rostral ventrolateral medulla evokes a pressor response in the rat and the rabbit. This region of the medulla gives rise to bulbospinal neurons containing many different neurotransmitters, including amines such as adrenaline, noradrenaline and serotonin, and neuropeptides such as substance P and neuropeptide Y. Colocalization of amines and neuropeptides has been described in some neurons descending from the rostral ventrolateral medulla. In this paper we discuss the evidence that bulbospinal serotonin-containing neurons (B3) and adrenaline-containing neurons (C1) arising from this part of the medulla exert pressor effects by distinct central pathways and conclude that they do. We also consider the possibility that the pressor effects of activating these two groups of neurons are associated with release of neuropeptides and highlight evidence that substance P is released into the spinal cord by activation of descending serotonin-containing neurons, while neuropeptide Y may be released by activation of bulbospinal adrenaline-containing neurons.

Original languageEnglish
Pages (from-to)1598-1604
Number of pages7
JournalCanadian Journal of Physiology and Pharmacology
Issue number8
Publication statusPublished - Aug 1987
Externally publishedYes


Dive into the research topics of 'Do pressor neurons in the ventrolateral medulla release amines and neuropeptides?'. Together they form a unique fingerprint.

Cite this