Abstract We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two‐thirds of colchicine‐treated patients improved after 48 hours, but only one‐third of the patients receiving placebo demonstrated similar improvement. The colchicine‐treated patients responded earlier; significant differences from placebo were shown after 18–30 hours. All patients given colchicine developed diarrhea after a median time of 24 hours (mean dose of colchicine 6.7 mg). This side effect occurred before relief of pain in most patients.
|Number of pages||4|
|Journal||Australian and New Zealand Journal of Medicine|
|Publication status||Published - Jun 1987|
- acute gout.