DOES COLCHICINE WORK? THE RESULTS OF THE FIRST CONTROLLED STUDY IN ACUTE GOUT

M. J. AHERN, C. REID, T. P. GORDON, M. McCREDlE, P. M. BROOKS, M. JONES

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Abstract

Abstract We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two‐thirds of colchicine‐treated patients improved after 48 hours, but only one‐third of the patients receiving placebo demonstrated similar improvement. The colchicine‐treated patients responded earlier; significant differences from placebo were shown after 18–30 hours. All patients given colchicine developed diarrhea after a median time of 24 hours (mean dose of colchicine 6.7 mg). This side effect occurred before relief of pain in most patients.

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalAustralian and New Zealand Journal of Medicine
Volume17
Issue number3
DOIs
Publication statusPublished - Jun 1987
Externally publishedYes

Keywords

  • acute gout.
  • Colchicine

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