DOES COLCHICINE WORK? THE RESULTS OF THE FIRST CONTROLLED STUDY IN ACUTE GOUT

M. J. AHERN; C. REID; T. P. GORDON; M. McCREDlE; P. M. BROOKS; M. JONES

doi:10.1111/j.1445-5994.1987.tb01232.x

DOES COLCHICINE WORK? THE RESULTS OF THE FIRST CONTROLLED STUDY IN ACUTE GOUT

M. J. AHERN, C. REID, T. P. GORDON, M. McCREDlE, P. M. BROOKS, M. JONES

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Abstract

Abstract We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two‐thirds of colchicine‐treated patients improved after 48 hours, but only one‐third of the patients receiving placebo demonstrated similar improvement. The colchicine‐treated patients responded earlier; significant differences from placebo were shown after 18–30 hours. All patients given colchicine developed diarrhea after a median time of 24 hours (mean dose of colchicine 6.7 mg). This side effect occurred before relief of pain in most patients.

Original language	English
Pages (from-to)	301-304
Number of pages	4
Journal	Australian and New Zealand Journal of Medicine
Volume	17
Issue number	3
DOIs	https://doi.org/10.1111/j.1445-5994.1987.tb01232.x
Publication status	Published - Jun 1987
Externally published	Yes

Keywords

acute gout.
Colchicine

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AU - REID, C.

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AU - McCREDlE, M.

AU - BROOKS, P. M.

AU - JONES, M.

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AB - Abstract We have performed the first controlled study of colchicine in acute gout, to determine its efficacy and toxicity, and to define the natural history of acute gout. Two‐thirds of colchicine‐treated patients improved after 48 hours, but only one‐third of the patients receiving placebo demonstrated similar improvement. The colchicine‐treated patients responded earlier; significant differences from placebo were shown after 18–30 hours. All patients given colchicine developed diarrhea after a median time of 24 hours (mean dose of colchicine 6.7 mg). This side effect occurred before relief of pain in most patients.

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DOES COLCHICINE WORK? THE RESULTS OF THE FIRST CONTROLLED STUDY IN ACUTE GOUT

Abstract

Keywords

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