Does the ileal brake mechanism contribute to sustained weight loss after bariatric surgery?

Savio G Barreto, Stijn Soenen, Jacob Andrew Chisholm, Ian Chapman, Lilian Kow

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Bariatric surgery is currently the most effective strategy for treating morbid obesity. Weight regain following significant weight loss, however, remains a problem, with the outcome proportional to the period of follow-up. This review revisits a well-established physiological neurohormonally-mediated feedback loop, the so called ileal brake mechanism, with a special emphasis on the gut hormone peptide tyrosine tyrosine. The manuscript not only highlights the potential role of the ileal brake mechanism in weight loss and weight maintenance thereafter following obesity surgery, it also provides a compelling argument for using this appetite suppressing feedback loop to enable sustained long-term weight loss in patients undergoing surgery for morbid obesity.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalANZ Journal of Surgery
Volume88
Issue number1-2
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • appetite and food intake
  • gut hormones
  • ileal brake
  • obesity surgery

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