Donor and recipient therapeutic manipulations to prevent corneal allograft rejection

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


    The outcome of corneal transplantation for dystrophic conditions such as keratoconus is excellent (1); visual results are usually good, and irreversible graft rejection, although not unknown (2), is quite uncommon. In virtually all other subsets of patients, however, corneal allograft rejection remains a major cause of graft failure (3). This point is well illustrated in Fig. 1, which shows actuarial graft survival for those patients who have received a corneal graft in our institution over the past 6 years. The actuarial 5-year graft survival rate for the subgroup with keratoconus is 96%; for the subgroup excluding keratoconus, it is 64%. For this latter group, 70% of grafts lost were considered to have failed from rejection.
    Original languageEnglish
    Title of host publicationThe Cornea
    Subtitle of host publicationTransactions of the World Congress on the Cornea III
    EditorsH. Dwight Cavanagh
    Place of PublicationNew York, U.S.A.
    PublisherRaven Press
    Number of pages8
    ISBN (Print)0881673730, 9780881673739
    Publication statusPublished - 1988


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