Dopamine helps worms deal with stress

Yee Lian Chew, William R. Schafer

Research output: Contribution to journalComment/debate


To maintain protein homoeostasis, animals have developed stress response pathways such as the ubiquitin proteasome system (UPS). Joshi and colleagues have demonstrated that in Caenorhabditis elegans, dopamine release from neurons acts on receptors in the epithelia to modulate protein turnover, by controlling the expression of regulators of the xenobiotic stress response. Dopamine receptor mutants challenged with pathogenic bacteria were defective in protein turnover and were also more sensitive to infection thus highlighting a role for monoamine signalling in innate immunity and stress responses.

Original languageEnglish
Pages (from-to)1851-1852
Number of pages2
JournalEMBO Journal
Issue number17
Publication statusPublished - 1 Sept 2016
Externally publishedYes


  • protein homoeostasis
  • animal stress
  • stress response
  • ubiquitin proteasome system (UPS)
  • Caenorhabditis elegans
  • monoamines


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