Dose, plasma concentration and response relationships of D-penicillamine in patients with rheumatoid arthritis

P. M. Brooks; J. O. Miners; K. Smith; Malcolm Smith; I. Fearnley; D. J. Birkett

Dose, plasma concentration and response relationships of D-penicillamine in patients with rheumatoid arthritis

P. M. Brooks, J. O. Miners, K. Smith, Malcolm Smith, I. Fearnley, D. J. Birkett

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14 Citations (Scopus)

Abstract

Plasma concentrations were measured in 10 patients with rheumatoid arthritis taking 250 mg, 500 mg and 750 mg of D-penicillamine daily. A disproportionate rise in the dose adjusted area under the plasma concentration vs time curve suggested dose dependent kinetics for D-penicillamine. Marked interindividual variability was seen with pharmacokinetic parameters and no correlations were observed between side effects or response and plasma concentrations of reduced D-penicillamine.

Original language	English
Pages (from-to)	772-775
Number of pages	4
Journal	Journal of Rheumatology
Volume	11
Issue number	6
Publication status	Published - 1 Dec 1984

Cite this

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abstract = "Plasma concentrations were measured in 10 patients with rheumatoid arthritis taking 250 mg, 500 mg and 750 mg of D-penicillamine daily. A disproportionate rise in the dose adjusted area under the plasma concentration vs time curve suggested dose dependent kinetics for D-penicillamine. Marked interindividual variability was seen with pharmacokinetic parameters and no correlations were observed between side effects or response and plasma concentrations of reduced D-penicillamine.",

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AU - Brooks, P. M.

AU - Miners, J. O.

AU - Smith, K.

AU - Smith, Malcolm

AU - Fearnley, I.

AU - Birkett, D. J.

PY - 1984/12/1

Y1 - 1984/12/1

N2 - Plasma concentrations were measured in 10 patients with rheumatoid arthritis taking 250 mg, 500 mg and 750 mg of D-penicillamine daily. A disproportionate rise in the dose adjusted area under the plasma concentration vs time curve suggested dose dependent kinetics for D-penicillamine. Marked interindividual variability was seen with pharmacokinetic parameters and no correlations were observed between side effects or response and plasma concentrations of reduced D-penicillamine.

AB - Plasma concentrations were measured in 10 patients with rheumatoid arthritis taking 250 mg, 500 mg and 750 mg of D-penicillamine daily. A disproportionate rise in the dose adjusted area under the plasma concentration vs time curve suggested dose dependent kinetics for D-penicillamine. Marked interindividual variability was seen with pharmacokinetic parameters and no correlations were observed between side effects or response and plasma concentrations of reduced D-penicillamine.

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Dose, plasma concentration and response relationships of D-penicillamine in patients with rheumatoid arthritis

Abstract

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