Dose, plasma concentration and response relationships of D-penicillamine in patients with rheumatoid arthritis

P. M. Brooks, J. O. Miners, K. Smith, Malcolm Smith, I. Fearnley, D. J. Birkett

    Research output: Contribution to journalArticle

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    Abstract

    Plasma concentrations were measured in 10 patients with rheumatoid arthritis taking 250 mg, 500 mg and 750 mg of D-penicillamine daily. A disproportionate rise in the dose adjusted area under the plasma concentration vs time curve suggested dose dependent kinetics for D-penicillamine. Marked interindividual variability was seen with pharmacokinetic parameters and no correlations were observed between side effects or response and plasma concentrations of reduced D-penicillamine.

    Original languageEnglish
    Pages (from-to)772-775
    Number of pages4
    JournalJournal of Rheumatology
    Volume11
    Issue number6
    Publication statusPublished - 1 Dec 1984

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