Dose-Related Effects of Alcohol on Cognitive Functioning

Matthew Dry, Nicholas Burns, Ted Nettelbeck, Aaron Farquharson, Jason White

    Research output: Contribution to journalArticle

    59 Citations (Scopus)

    Abstract

    We assessed the suitability of six applied tests of cognitive functioning to provide a single marker for dose-related alcohol intoxication. Numerous studies have demonstrated that alcohol has a deleterious effect on specific areas of cognitive processing but few have compared the effects of alcohol across a wide range of different cognitive processes. Adult participants (N = 56, 32 males, 24 females aged 18-45 years) were randomized to control or alcohol treatments within a mixed design experiment involving multiple-dosages at approximately one hour intervals (attained mean blood alcohol concentrations (BACs) of 0.00, 0.048, 0.082 and 0.10%), employing a battery of six psychometric tests; the Useful Field of View test (UFOV; processing speed together with directed attention); the Self-Ordered Pointing Task (SOPT; working memory); Inspection Time (IT; speed of processing independent from motor responding); the Traveling Salesperson Problem (TSP; strategic optimization); the Sustained Attention to Response Task (SART; vigilance, response inhibition and psychomotor function); and the Trail-Making Test (TMT; cognitive flexibility and psychomotor function). Results demonstrated that impairment is not uniform across different domains of cognitive processing and that both the size of the alcohol effect and the magnitude of effect change across different dose levels are quantitatively different for different cognitive processes. Only IT met the criteria for a marker for wide-spread application: reliable dose-related decline in a basic process as a function of rising BAC level and easy to use non-invasive task properties.

    Original languageEnglish
    Article numbere50977
    Pages (from-to)e50977
    Number of pages8
    JournalPLoS One
    Volume7
    Issue number11
    DOIs
    Publication statusPublished - 29 Nov 2012

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  • Cite this

    Dry, M., Burns, N., Nettelbeck, T., Farquharson, A., & White, J. (2012). Dose-Related Effects of Alcohol on Cognitive Functioning. PLoS One, 7(11), e50977. [e50977]. https://doi.org/10.1371/journal.pone.0050977