Drug Burden Index in older adults: theoretical and practical issues

Lisa Kouladjian, Danijela Gnjidic, Timothy Chen, Arduino Mangoni, Sarah Hilmer

    Research output: Contribution to journalReview articlepeer-review

    107 Citations (Scopus)


    Anticholinergic and sedative medications are commonly used in older adults and are associated with adverse clinical outcomes. The Drug Burden Index was developed to measure the cumulative exposure to these medications in older adults and its impact on physical and cognitive function. This narrative review discusses the research and clinical applications of the Drug Burden Index, and its advantages and limitations, compared with other pharmacologically developed measures of high-risk prescribing.

    Original languageEnglish
    Pages (from-to)1503-1515
    Number of pages13
    JournalClinical Interventions in Aging
    Publication statusPublished - 9 Sept 2014


    • Anticholinergics
    • Deprescribing
    • Drug burden index
    • High-risk prescribing
    • Older adults
    • Pharmacological risk assessment tools
    • Sedative medications


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