Drugs acting on the cerebral and peripheral circulations

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    The Side Effects of Drugs Annuals form a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. The series supplements the contents of Meyler's Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and Interactions. This review of the 2011 publications on drugs that act on the cerebral and peripheral circulations covers buflomedil, cilostazol, pentoxifylline, diosmin, ergot alkaloids, the triptans, and inhibitors of phosphodiesterase type V. The risk of buflomedil toxicity in patients with impaired renal function using current French dosage guidelines has been estimated at about 6%. Leukopenia has been attributed to pentoxifylline. Ergot alkaloids have been shown to have direct cytotoxic effects in two primary human cell lines. Myocardial infarction with coronary vasospasm on angiography has been associated with a triptan. The co-administration of sildenafil and hydrochlorothiazide may have been responsible for a case of hypotension triggering acute spinal cord infarction. Increased choroidal thickness has been attributed to sildenafil. Tadalafil might have triggered visual scotomata as a manifestation of Leber's hereditary optic neuropathy.

    Original languageEnglish
    Title of host publicationSide Effects of Drugs Annual
    PublisherElsevier
    Chapter19
    Pages359-362
    Number of pages4
    Volume35
    Edition1st
    ISBN (Print)9780444626356
    DOIs
    Publication statusPublished - 2014

    Publication series

    NameSide Effects of Drugs Annual
    Volume35
    ISSN (Print)0378-6080

    Keywords

    • Adverse reactions
    • Buflomedil
    • Cilostazol
    • Diosmin
    • Ergot alkaloids
    • Inhibitors of phosphodiesterase type V
    • Pentoxifylline
    • Triptans

    Fingerprint Dive into the research topics of 'Drugs acting on the cerebral and peripheral circulations'. Together they form a unique fingerprint.

  • Cite this

    Mangoni, A. (2014). Drugs acting on the cerebral and peripheral circulations. In Side Effects of Drugs Annual (1st ed., Vol. 35, pp. 359-362). (Side Effects of Drugs Annual; Vol. 35). Elsevier. https://doi.org/10.1016/B978-0-444-62635-6.00019-X