Drugs Acting on the Cerebral and Peripheral Circulations

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Cilostazol caused increased accumulation of donepezil in cardiomyocytes by inhibiting breast cancer resistance protein. This might explain the increased risk of cardiotoxicity when donepezil is co-administered with cilostazol. High-dose vitamin E induced significant changes in biomarkers of inflammation and toxicity in kidney tissue of male, but not female, mice. Furthermore, vitamin E induced a significant increase in phase-I, but not phase-II, carcinogen bio-activating enzymes and a reduction in antioxidant enzyme activities. Benzbromarone significantly inhibited CYP2C9 and CYP3A4 activity in human liver microsomes, suggesting a possible involvement of CYP450 inhibition in the occurrence of benzbromarone-induced hepatotoxicity. In healthy volunteers, diosmin significantly inhibited P-glycoprotein and CYP3A4 activity, with consequent increased exposure to fexofenadine and carbamazepine, respectively. A case of erythema multiforme related to sildenafil use was reported. In an experimental model of epilepsy, the pro-convulsant effects of sildenafil were mediated by oxytocin and cyclic AMP response element-binding protein.

    Original languageEnglish
    Title of host publicationSide Effects of Drugs Annual
    EditorsSidhartha D. Ray
    PublisherElsevier
    Pages179-181
    Number of pages3
    Volume39
    ISBN (Print)9780444639486
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Cardiotoxicity
    • Drug–drug interactions
    • Epilepsy
    • Erythema multiforme
    • Hepatotoxicity
    • Macular atrophy
    • Tumorigenicity

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