Abstract
Cilostazol caused increased accumulation of donepezil in cardiomyocytes by inhibiting breast cancer resistance protein. This might explain the increased risk of cardiotoxicity when donepezil is co-administered with cilostazol. High-dose vitamin E induced significant changes in biomarkers of inflammation and toxicity in kidney tissue of male, but not female, mice. Furthermore, vitamin E induced a significant increase in phase-I, but not phase-II, carcinogen bio-activating enzymes and a reduction in antioxidant enzyme activities. Benzbromarone significantly inhibited CYP2C9 and CYP3A4 activity in human liver microsomes, suggesting a possible involvement of CYP450 inhibition in the occurrence of benzbromarone-induced hepatotoxicity. In healthy volunteers, diosmin significantly inhibited P-glycoprotein and CYP3A4 activity, with consequent increased exposure to fexofenadine and carbamazepine, respectively. A case of erythema multiforme related to sildenafil use was reported. In an experimental model of epilepsy, the pro-convulsant effects of sildenafil were mediated by oxytocin and cyclic AMP response element-binding protein.
Original language | English |
---|---|
Title of host publication | Side Effects of Drugs Annual |
Editors | Sidhartha D. Ray |
Publisher | Elsevier |
Pages | 179-181 |
Number of pages | 3 |
Volume | 39 |
ISBN (Print) | 9780444639486 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- Cardiotoxicity
- Drug–drug interactions
- Epilepsy
- Erythema multiforme
- Hepatotoxicity
- Macular atrophy
- Tumorigenicity