Drugs acting on the cerebral and peripheral circulations

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    In a systematic review of observational studies the intensity of exposure to ergotamine, but not to triptans, was associated with increased incidence of serious cardiovascular outcomes in patients with migraine. A national pharmacoepidemiological study showed that use of triptans in the second trimester of pregnancy was associated with increased risk of post-partum haemorrhage. In the same study, use of triptans before pregnancy was associated with increased risk of congenital malformations, low birth weight and pre-term birth. A case of acute haemolytic anaemia possibly related to Ginkgo biloba leaf extract was reported. Two cases of possible muscle damage with raised creatinine kinase and lactate dehydrogenase concentrations were associated with the use of diosmin. In vitro studies described potential mechanisms responsible for Ginkgo biloba-associated tumorigenicity and genotoxicity, benzbromarone-associated liver toxicity, and tadalafil-associated alterations in hepatic glucose homeostasis.

    Original languageEnglish
    Title of host publicationSide Effects of Drugs Annual
    EditorsSidhartha D. Ray
    PublisherElsevier
    Chapter19
    Pages223-226
    Number of pages4
    Volume37
    ISBN (Print)9780444635259
    DOIs
    Publication statusPublished - 2015

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  • Cite this

    Mangoni, A. (2015). Drugs acting on the cerebral and peripheral circulations. In S. D. Ray (Ed.), Side Effects of Drugs Annual (Vol. 37, pp. 223-226). Elsevier. https://doi.org/10.1016/bs.seda.2015.06.004