Dual Silane Surface Functionalization for the Selective Attachment of Human Neuronal Cells to Porous Silicon

Martin Sweetman, Cameron Shearer, Joseph Shapter, Nicolas Voelcker

    Research output: Contribution to journalArticle

    66 Citations (Scopus)

    Abstract

    Porous silicon (pSi) surfaces were chemically micropatterned through a combination of photolithography and surface silanization reactions. This patterning technique produces discretely defined regions on a pSi surface functionalized with a specific chemical functionality, and the surrounding surface displays a completely different functionality. The generated chemical patterns were characterized by a combination of IR microscopy and the conjugation of two different fluorescent organic dyes. Finally, the chemically patterned pSi surface was used to direct the attachment of neuronal cells to the surface. This patterning strategy will be useful for the development of high-throughput platforms for investigating cell behavior.

    Original languageEnglish
    Pages (from-to)9497-9503
    Number of pages7
    JournalLangmuir
    Volume27
    Issue number15
    DOIs
    Publication statusPublished - 2 Aug 2011

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