Dynorphin-containing pilomotor neurons in the superior cervical ganglion of guinea pigs

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    Abstract

    Retrograde axonal tracing and double-labelling immunofluorescence have been combined to determine the neuropeptide content of identified pilomotor neurons in the superior cervical ganglion of guinea pigs. These neurons lacked immunoreactivity to neuropeptide Y (NPY) but they generally contained low levels of immunoreactivity to prodynorphin-derived peptides, including dynorphin A(1-8), dynorphin A(1-17), and α-neo-endorphin. Thus pilomotor neurons are neurochemically distinct from superior cervical ganglion cells which contain immunoreactivity to NPY and prodynorphin-derived peptides and which innervate the iris and most of the vasculature in the head of guinea pigs. They are also distinct from sympathetic secretomotor neurons which lack both NPY and prodynorphin-derived peptides.

    Original languageEnglish
    Pages (from-to)45-50
    Number of pages6
    JournalNeuroscience letters
    Volume107
    Issue number1-3
    DOIs
    Publication statusPublished - 15 Dec 1989

    Keywords

    • Co-existence
    • Dynorphin
    • Guinea pig
    • Immunofluorescence
    • Neuropeptide Y
    • Pilomotor neuron
    • Retrograde axonal tracing
    • Sympathetic

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