Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from a Dysidea sp. Marine Sponge

Wei-Hua Jiao, Guo-Hua Shi, Ting-Ting Xu, Guo-Dong Chen, Bin-Bin Gu, Zhuo Wang, Shuang Peng, Shu-Ping Wang, Jia Li, Bing-Nan Han, Wei Zhang, Hou-Wen Lin

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    23 Citations (Scopus)

    Abstract

    Four new tetracyclic meroterpnes, dysiherbols A-C (1-3) and dysideanone E (4), were isolated from a Dysidea sp. marine sponge collected from the South China Sea. Their complete structures and absolute configurations were unambiguously determined by a combination of NMR spectroscopic data, ECD calculations, and single-crystal X-ray diffraction analysis. Within the sesquiterpene quinol structures, dysiherbols A-C possess an intriguing 6/6/5/6-fused tetracyclic carbon skeleton. The NF-κB inhibitory and cytotoxic activity evaluation disclosed that dysiherbol A (1) showed potent activity with respective IC50 values of 0.49 and 0.58 μM, which were about 10-fold and 20-fold more potent than those of dysiherbols B (2) and C (3), which feature hydroxy and ketone carbonyl groups at the C-3 position.

    Original languageEnglish
    Pages (from-to)406-411
    Number of pages6
    JournalJournal of Natural Products
    Volume79
    Issue number2
    DOIs
    Publication statusPublished - 26 Feb 2016

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