Dysiherbols A–C and dysideanone E, cytotoxic and NF-kB inhibitory tetracyclic meroterpenes from a Dysidea sp. Marine Sponge

Wei-Hua Jiao, Guo-Hua Shi, Ting-Ting Xu, Guo-Dong Chen, Bin-Bin Gu, Zhuo Wang, Shuang Peng, Shu-Ping Wang, Jia Li, Bing-Nan Han, Wei Zhang, Hou-Wen Lin

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    Abstract

    Four new tetracyclic meroterpnes, dysiherbols A-C (1-3) and dysideanone E (4), were isolated from a Dysidea sp. marine sponge collected from the South China Sea. Their complete structures and absolute configurations were unambiguously determined by a combination of NMR spectroscopic data, ECD calculations, and single-crystal X-ray diffraction analysis. Within the sesquiterpene quinol structures, dysiherbols A-C possess an intriguing 6/6/5/6-fused tetracyclic carbon skeleton. The NF-κB inhibitory and cytotoxic activity evaluation disclosed that dysiherbol A (1) showed potent activity with respective IC50 values of 0.49 and 0.58 μM, which were about 10-fold and 20-fold more potent than those of dysiherbols B (2) and C (3), which feature hydroxy and ketone carbonyl groups at the C-3 position.

    Original languageEnglish
    Pages (from-to)406-411
    Number of pages11
    JournalJournal of Natural Products
    Volume79
    Issue number2
    DOIs
    Publication statusPublished - 2016

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    Jiao, W-H., Shi, G-H., Xu, T-T., Chen, G-D., Gu, B-B., Wang, Z., Peng, S., Wang, S-P., Li, J., Han, B-N., Zhang, W., & Lin, H-W. (2016). Dysiherbols A–C and dysideanone E, cytotoxic and NF-kB inhibitory tetracyclic meroterpenes from a Dysidea sp. Marine Sponge. Journal of Natural Products, 79(2), 406-411. https://doi.org/10.1021/acs.jnatprod.5b01079