Economic analysis of endovascular interventions for femoropopliteal arterial disease: A systematic review and budget impact model for the United States and Germany

Jan B. Pietzsch, Benjamin P. Geisler, Abigail M. Garner, Thomas Zeller, Michael R. Jaff

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objectives

To study the economic impact on payers and providers of the four main endovascular strategies for the treatment of infrainguinal peripheral artery disease.

Background

Bare metal stents (BMS), drug-eluting stents (DES), and drug-coated balloons (DCB) are associated with lower target lesion revascularization (TLR) probabilities than percutaneous transluminal angioplasty (PTA), but the economic impact is unknown.

Methods

In December 2012, PubMed and Embase were systematically searched for studies with TLR as an endpoint. The 24-month probability of TLR for each treatment was weighted by sample size. A decision-analytic Markov model was used to assess the budget impact from payers' and facility-providers' perspectives of the four index procedure strategies (BMS, DES, DCB, and PTA). Base cases were developed for U.S. Medicare and the German statutory sickness fund perspectives using current 2013 reimbursement rates.

Results

Thirteen studies with 2,406 subjects were included. The reported probability of TLR in the identified studies varied widely, particularly following treatment with PTA or BMS. The pooled 24-month probabilities were 14.3%, 19.3%, 28.1%, and 40.3% for DCB, DES, BMS, and PTA, respectively. The drug-eluting strategies had a lower projected budget impact over 24 months compared to BMS and PTA in both the U.S. Medicare (DCB: 10,214; DES: 12,904; uncoated balloons 13,114; BMS 13,802) and German public health care systems (DCB €3,619; DES €3,632; BMS €4,026; PTA €4,290).

Conclusions

DCB and DES, compared to BMS and PTA, are associated with lower probabilities of target lesion revascularization and cost savings for U.S. and German payers.

Original languageEnglish
Pages (from-to)546-554
Number of pages9
JournalCatheterization and Cardiovascular Interventions
Volume84
Issue number4
DOIs
Publication statusPublished - 1 Oct 2014
Externally publishedYes

Keywords

  • balloon
  • balloon angioplasty
  • drug coated/eluting
  • drug eluting
  • economics/cost-effectiveness
  • endovascular intervention
  • peripheral arterial disease
  • stent

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