Economic evaluation alongside n-of-1 trials: getting closer to the margin

Jonathan Karnon, Nawab Qizilbash

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The n‐of‐1 trial is a particularly flexible form of randomized controlled trial that involves a single patient receiving multiple episodes of alternative therapies. Although n‐of‐1 trials are only applicable in certain treatment areas, the collection of economic data within such trials may provide unique advantages. This paper illustrates the issues around the use of economic n‐of‐1 trials with a hypothetical example, and discusses their potential for the estimation of individualized cost‐effectiveness. Copyright © 2001 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalHealth Economics
Issue number1
Publication statusPublished - 22 Jan 2001
Externally publishedYes


  • clinical evaluation
  • patient preferences
  • individualized funding


Dive into the research topics of 'Economic evaluation alongside n-of-1 trials: getting closer to the margin'. Together they form a unique fingerprint.

Cite this