Editorial: Defective DNA damage response–Repair axis in post-mitotic neurons in human health and neurodegenerative diseases

Anna Konopka, Julie D. Atkin, Joy Mitra

Research output: Contribution to journalEditorial

17 Downloads (Pure)

Abstract

Efficient DNA repair processes are essential for the maintenance of genomic integrity and therefore cellular homeostasis. Due to their post-mitotic nature, neurons cannot be replenished like other cell types and thus they must deal with DNA lesions throughout their lifespan, implying that DNA damage is particularly deleterious to these cells. DNA damage accumulates in neurodegenerative diseases, and thus may contribute to the selective death of specific types of neurons. However, DNA lesions are required for the regulation of neuronal gene expression and synaptic function and thus DNA damage is significant in normal physiological processes.
Original languageEnglish
Article number1009760
Number of pages2
JournalFrontiers in Cellular Neuroscience
Volume16
DOIs
Publication statusPublished - 23 Aug 2022
Externally publishedYes

Keywords

  • DNA damage
  • DNA repair
  • neurodegeneration
  • neurons
  • post-mitotic

Fingerprint

Dive into the research topics of 'Editorial: Defective DNA damage response–Repair axis in post-mitotic neurons in human health and neurodegenerative diseases'. Together they form a unique fingerprint.

Cite this