Editorial: Synovial tissue biopsy research

Douglas J. Veale, Gary S. Firestein, Mihir D. Wechalekar, Aurélie Najm

Research output: Contribution to journalEditorial

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Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, that left untreated results in pain, joint damage, and functional disability for the patients. In healthy persons, the synovium is a loose connective tissue with one or two cells lining the surface without a basement membrane. It adheres to the internal joint capsule, which is comprised of ligaments. In RA, the synovium expands with finger-like projections (villi) that are highly vascularised with new blood vessels and abundant activated immune cells including macrophages, lymphocytes, and resident stromal cells, i.e., fibroblasts and dendritic cells.
Original languageEnglish
Article number1004029
Number of pages3
JournalFrontiers in Medicine
Publication statusPublished - 4 Oct 2022


  • rheumatoid arthritis
  • Psoriatic arthritis
  • synovial tissue
  • biopsies
  • cellular and molecular analysis


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