Effect of breathing helium on sympathetic nervous and cardiovascular functions

T. E. Nicholas; J. L. Hart; P. A. Kim

Effect of breathing helium on sympathetic nervous and cardiovascular functions

T. E. Nicholas, J. L. Hart, P. A. Kim

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Following the suggestion that the antiarrhythmic action of helium is mediated by changes in sympathetic activity, the effect of He O₂ (80:20) on sympathetic function was investigated. The unanesthetized rat with indwelling cannulae and the pithed rat both responded to norepinephrine (NE), tyramine, and dimethylphenylpiperazinium similarly in He O₂ (31°C) as in air (36°C). Furthermore, He O₂ failed to alter the depressor response to a 45° tail down tilt in either rats or guinea pigs. Likewise, He O₂ did not alter the response of the cat nictitatingl25w10=discussed membrane to preganglionic stimulation. Finally, the effect of He O₂ on the turnover of cardiac NE was examined. Following injection of ³H L NE, the turnover of NE, as measured by the rate of fall of tritium and the endogenous level of NE, was identical in rats exposed to He O₂ (31°C) and to air (26°C). It is concluded that helium does not affect sympathetic nervous or cardiovascular function in the species studied.

Original language	English
Pages (from-to)	271-280
Number of pages	10
Journal	Undersea Biomedical Research
Volume	1
Issue number	3
Publication status	Published - 1 Dec 1974
Externally published	Yes

Cite this

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title = "Effect of breathing helium on sympathetic nervous and cardiovascular functions",

abstract = "Following the suggestion that the antiarrhythmic action of helium is mediated by changes in sympathetic activity, the effect of He O2 (80:20) on sympathetic function was investigated. The unanesthetized rat with indwelling cannulae and the pithed rat both responded to norepinephrine (NE), tyramine, and dimethylphenylpiperazinium similarly in He O2 (31°C) as in air (36°C). Furthermore, He O2 failed to alter the depressor response to a 45° tail down tilt in either rats or guinea pigs. Likewise, He O2 did not alter the response of the cat nictitatingl25w10=discussed membrane to preganglionic stimulation. Finally, the effect of He O2 on the turnover of cardiac NE was examined. Following injection of 3H L NE, the turnover of NE, as measured by the rate of fall of tritium and the endogenous level of NE, was identical in rats exposed to He O2 (31°C) and to air (26°C). It is concluded that helium does not affect sympathetic nervous or cardiovascular function in the species studied.",

author = "Nicholas, {T. E.} and Hart, {J. L.} and Kim, {P. A.}",

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TY - JOUR

T1 - Effect of breathing helium on sympathetic nervous and cardiovascular functions

AU - Nicholas, T. E.

AU - Hart, J. L.

AU - Kim, P. A.

PY - 1974/12/1

Y1 - 1974/12/1

N2 - Following the suggestion that the antiarrhythmic action of helium is mediated by changes in sympathetic activity, the effect of He O2 (80:20) on sympathetic function was investigated. The unanesthetized rat with indwelling cannulae and the pithed rat both responded to norepinephrine (NE), tyramine, and dimethylphenylpiperazinium similarly in He O2 (31°C) as in air (36°C). Furthermore, He O2 failed to alter the depressor response to a 45° tail down tilt in either rats or guinea pigs. Likewise, He O2 did not alter the response of the cat nictitatingl25w10=discussed membrane to preganglionic stimulation. Finally, the effect of He O2 on the turnover of cardiac NE was examined. Following injection of 3H L NE, the turnover of NE, as measured by the rate of fall of tritium and the endogenous level of NE, was identical in rats exposed to He O2 (31°C) and to air (26°C). It is concluded that helium does not affect sympathetic nervous or cardiovascular function in the species studied.

AB - Following the suggestion that the antiarrhythmic action of helium is mediated by changes in sympathetic activity, the effect of He O2 (80:20) on sympathetic function was investigated. The unanesthetized rat with indwelling cannulae and the pithed rat both responded to norepinephrine (NE), tyramine, and dimethylphenylpiperazinium similarly in He O2 (31°C) as in air (36°C). Furthermore, He O2 failed to alter the depressor response to a 45° tail down tilt in either rats or guinea pigs. Likewise, He O2 did not alter the response of the cat nictitatingl25w10=discussed membrane to preganglionic stimulation. Finally, the effect of He O2 on the turnover of cardiac NE was examined. Following injection of 3H L NE, the turnover of NE, as measured by the rate of fall of tritium and the endogenous level of NE, was identical in rats exposed to He O2 (31°C) and to air (26°C). It is concluded that helium does not affect sympathetic nervous or cardiovascular function in the species studied.

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C2 - 4469095

AN - SCOPUS:0016275893

SN - 0093-5387

VL - 1

SP - 271

EP - 280

JO - Undersea Biomedical Research

JF - Undersea Biomedical Research

IS - 3

ER -

Effect of breathing helium on sympathetic nervous and cardiovascular functions

Abstract

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