Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease

Angelo Zinellu, Salvatore Sotgia, Arduino Mangoni, Elisabetta Sotgiu, Sara Ena, Andrea Satta, Ciriaco Carru

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    The elevated cardiovascular morbidity and mortality in chronic kidney disease (CKD) is linked with endothelial dysfunction secondary to the pro-inflammatory and pro-oxidative state typical of this pathology. In consideration of the well-known pleiotropic effect of statins, we investigated the effect of cholesterol lowering treatment on endothelial dysfunction markers (MED), asymmetric dimethylarginine (ADMA), vascular cell (VCAM) and intercellular (ICAM) adhesion molecule. Plasma MED concentrations, inflammation and oxidative stress indices [Kynurenine/Tryptophan (Kyn/Trp) ratio, malondialdehyde (MDA) and allantoin/uric acid (All/UA) ratio] were measured in 30 CKD patients randomized to three cholesterol lowering regimens for 12 months (simvastatin 40 mg/day, ezetimibe/simvastatin 10/20 mg/day, or ezetimibe/simvastatin 10/40 mg/day). Treatment significantly reduced ADMA concentrations in all patients [0.694 μmol/L (0.606–0.761) at baseline vs. 0.622 μmol/L (0.563–0.681) after treatment, p < 0.001]. ADMA reduction was paralleled by a significant decrease of MDA, All/AU ratio and Kyn/Trp ratio, but not VCAM and ICAM plasma concentrations. Cholesterol lowering treatment was associated with a significant reduction in plasma ADMA concentrations in CKD patients. This might be mediated by reduced oxidative stress and inflammation.

    Original languageEnglish
    Pages (from-to)383-388
    Number of pages6
    JournalJournal of Pharmaceutical and Biomedical Analysis
    Volume129
    DOIs
    Publication statusPublished - 10 Sep 2016

    Keywords

    • Asymmetric dimethylarginine
    • Chronic kidney disease
    • Ezetimibe
    • Intercellular adhesion molecule
    • Oxidative stress
    • Simvastatin
    • Vascular cell adhesion molecule

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