TY - JOUR
T1 - Effect of continuous positive airway pressure on blood pressure in normotensive individuals with obstructive sleep apnoea
T2 - A randomised trial
AU - Targa, Adriano D. S.
AU - Torres, Gerard
AU - Benitez, Iván D.
AU - Henriquez-Beltran, Mario
AU - Vaca, Rafaela
AU - Pascual Arno, Lidia
AU - Minguez, Olga
AU - Aguilà, Maria
AU - Martínez, Dolores
AU - Pinilla, Lucia
AU - Galan Gonzalez, Anna
AU - Balsells Garriga, Sergi
AU - Sanchez-de-la-Torre, Manuel
AU - Barbé, Ferran
PY - 2025/7
Y1 - 2025/7
N2 - Background: The effects of continuous positive airway pressure (CPAP) on blood pressure (BP) in normotensive subjects, particularly among those with a dipping BP pattern, remain uncertain, raising questions about its indication for this group of patients. We assessed the impact of CPAP on BP in normotensive subjects with a dipping BP pattern and severe obstructive sleep apnoea (OSA). Methods: This was a randomised, parallel, prospective, controlled trial. Inclusion criteria were: age ≥18 years, apnoea–hypopnoea index ≥30 events·h −1, mean 24-h BP <130/80 mmHg and daytime to nighttime BP reduction ≥10%. Patients were randomly assigned to receive either CPAP treatment or usual care for 12 weeks. The primary outcome was the change in ambulatory BP monitoring (ABPM) parameters from baseline to the 3-month follow-up. Results: The 60 patients who completed the follow-up had a mean±SD age of 52.2±10.8 years and 40 (66.7%) were male. The intention-to-treat analysis showed no significant changes with CPAP, whereas the usual care group experienced increases in ABPM parameters. This resulted in a mean difference of −3.4 mmHg (95% CI −6.124– −0.676; p=0.015) in night-time diastolic BP between the groups. The per-protocol analysis indicated significant differences between the CPAP and usual care groups for all primary end-points, except for daytime systolic BP. For night-time systolic BP, the mean difference was −6.052 mmHg (95% CI −10.895– −1.208; p=0.016). Conclusion: These findings suggest a protective effect of CPAP, highlighting the importance of CPAP prescription for this population to control potential increases in BP and possibly prevent the onset of hypertension.
AB - Background: The effects of continuous positive airway pressure (CPAP) on blood pressure (BP) in normotensive subjects, particularly among those with a dipping BP pattern, remain uncertain, raising questions about its indication for this group of patients. We assessed the impact of CPAP on BP in normotensive subjects with a dipping BP pattern and severe obstructive sleep apnoea (OSA). Methods: This was a randomised, parallel, prospective, controlled trial. Inclusion criteria were: age ≥18 years, apnoea–hypopnoea index ≥30 events·h −1, mean 24-h BP <130/80 mmHg and daytime to nighttime BP reduction ≥10%. Patients were randomly assigned to receive either CPAP treatment or usual care for 12 weeks. The primary outcome was the change in ambulatory BP monitoring (ABPM) parameters from baseline to the 3-month follow-up. Results: The 60 patients who completed the follow-up had a mean±SD age of 52.2±10.8 years and 40 (66.7%) were male. The intention-to-treat analysis showed no significant changes with CPAP, whereas the usual care group experienced increases in ABPM parameters. This resulted in a mean difference of −3.4 mmHg (95% CI −6.124– −0.676; p=0.015) in night-time diastolic BP between the groups. The per-protocol analysis indicated significant differences between the CPAP and usual care groups for all primary end-points, except for daytime systolic BP. For night-time systolic BP, the mean difference was −6.052 mmHg (95% CI −10.895– −1.208; p=0.016). Conclusion: These findings suggest a protective effect of CPAP, highlighting the importance of CPAP prescription for this population to control potential increases in BP and possibly prevent the onset of hypertension.
KW - continuous positive airway pressure
KW - CPAP
KW - hypertension
KW - randomised controlled trial
UR - http://www.scopus.com/inward/record.url?scp=105011978428&partnerID=8YFLogxK
U2 - 10.1183/13993003.01954-2024
DO - 10.1183/13993003.01954-2024
M3 - Article
AN - SCOPUS:105011978428
SN - 1399-3003
VL - 66
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 1
M1 - 2401954
ER -