Effect of cyclosporin A on the survival of corneal grafts in rabbits

W. F. I. Shepherd, D. J. Coster, T. Chin Fook, N. S. C. Rice, B. R. Jones

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Cyclosporin A given to rabbits intramuscularly in a dose of 25 mg/kg/day for up to 28 days after corneal transfer results in a marked prolongation in the survival of penetrating corneal grafts compared to that in an untreated control group. Cyclosporin A 1% drops did not prolong survival of the corneal graft, but this may be related to the need for skin transfer 14 days after corneal transfer to ensure rejection, and supports the idea that the drug plays an immunosuppressive role at the time and place of sensitisation.

Original languageEnglish
Pages (from-to)148-153
Number of pages6
JournalBritish Journal of Ophthalmology
Issue number3
Publication statusPublished - 1 Jan 1980
Externally publishedYes


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