Effect of dietary restriction on in vivo somatic mutation in mice

J. L. Dempsey, M. Pfeiffer, A. A. Morley

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)


Dietary restriction is the one experimental variable which has been shown reproducibly to retard ageing. The effect of dietary restriction on in vivo mutation was studied in mice by feeding experimental mice 60% of the amount eaten by control mice and measuring mutations in lymphocytes at the hypoxanthine phosphoribosyl transferase locus at 4 weeks, 6 months and 12 months of age. Dietary restriction markedly decreased the age-associated accumulation of mutations observed in control mice, which suggests that somatic mutation is involved in the ageing process and that the majority of in vivo mutations result from dietary factors.

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalMutation Research/Environmental Mutagenesis and Related Subjects
Issue number2
Publication statusPublished - Apr 1993
Externally publishedYes


  • Ageing
  • Diet
  • Lymphocytes
  • Mouse


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