Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial

Joyce Ramos; Lance Dalleck; Rebecca Stennett; Gregore Iven  Mielke; Shelley E. Keating; Lydia Murray; Sumaira Hasnain; Robert Fassett; Michael McGuckin; Ilaria Croci; Jeff Coombes

doi:10.2147/DMSO.S251567

Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial

Joyce Ramos, Lance Dalleck, Rebecca Stennett, Gregore Iven Mielke, Shelley E. Keating, Lydia Murray, Sumaira Hasnain, Robert Fassett, Michael McGuckin, Ilaria Croci, Jeff Coombes

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Abstract

Introduction: IL-22 may have a role in the alleviation of the metabolic syndrome (MetS) via protection of pancreatic beta and endothelial cells from oxidative and lipid-induced damage. We aimed to investigate the effects of moderate-intensity continuous training (MICT) and different volumes of high-intensity interval training (HIIT) on changes in circulating IL-22.
Methods: This was a sub-study of the “Exercise in the prevention of Metabolic Syndrome” (EX-MET) a multi-center, randomized trial. This study used data collected at the Brisbane site. Thirty-nine individuals with MetS were randomized to one of three 16-wk interventions: 1) MICT (n=10, 30min at 60– 70% HR peak, 5x/wk); 2) 4HIIT (n=13, 4x4min at 85– 95% HR peak, interspersed with 3min of active recovery at 50– 70% HR peak, 3x/wk); or 3) 1HIIT (n=16, 1x4min at 85– 95% HR peak, 3x/wk). Serum IL-22 concentration was measured following a 12-hr fast via an enzyme linked immunosorbent assay, before and after the intervention. MetS severity, insulin resistance (IR), visceral adipose tissue (VAT), and cardiorespiratory fitness (CRF) were also measured via MetS z-score, HOMA-IR, dual-energy X-ray absorptiometry, and indirect calorimetry (maximal exercise test), respectively.
Results: The median (IQR) IL-22% changes from pre- to post-intervention in the MICT, 4HIIT, and 1HIIT groups were − 17% (− 43.0% to 31.3%), +16.5% (− 18.9% to 154.9%), and +15.9% (− 28.7% to 46.1%), respectively. Although there were no significant between-group differences in IL-22 concentration change, there was a medium-to-large group × time interaction effect [F(2,35)=2.08, p=0.14, η2=0.14].
Conclusion: Although there was no statistically significant between-group difference in IL-22 change, the study suggests that different exercise intensities may have opposing effects on IL-22 concentration in individuals with MetS.

Original language	English
Pages (from-to)	2443-2453
Number of pages	11
Journal	Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Volume	13
DOIs	https://doi.org/10.2147/DMSO.S251567
Publication status	Published - 9 Jul 2020

Bibliographical note

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution–Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing thework you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Forpermission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

Keywords

high-intensity interval training
IL-22
inflammation
cardiovascular disease
metabolic syndrome
cytokine
Cytokine
High-intensity interval training
Cardiovascular disease
Inflammation
Metabolic syndrome

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Ramos, J., Dalleck, L., Stennett, R., Mielke, G. I., Keating, S. E., Murray, L., Hasnain, S., Fassett, R., McGuckin, M., Croci, I., & Coombes, J. (2020). Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 13, 2443-2453. https://doi.org/10.2147/DMSO.S251567

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title = "Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial",

abstract = "Introduction: IL-22 may have a role in the alleviation of the metabolic syndrome (MetS) via protection of pancreatic beta and endothelial cells from oxidative and lipid-induced damage. We aimed to investigate the effects of moderate-intensity continuous training (MICT) and different volumes of high-intensity interval training (HIIT) on changes in circulating IL-22.Methods: This was a sub-study of the “Exercise in the prevention of Metabolic Syndrome” (EX-MET) a multi-center, randomized trial. This study used data collected at the Brisbane site. Thirty-nine individuals with MetS were randomized to one of three 16-wk interventions: 1) MICT (n=10, 30min at 60– 70% HR peak, 5x/wk); 2) 4HIIT (n=13, 4x4min at 85– 95% HR peak, interspersed with 3min of active recovery at 50– 70% HR peak, 3x/wk); or 3) 1HIIT (n=16, 1x4min at 85– 95% HR peak, 3x/wk). Serum IL-22 concentration was measured following a 12-hr fast via an enzyme linked immunosorbent assay, before and after the intervention. MetS severity, insulin resistance (IR), visceral adipose tissue (VAT), and cardiorespiratory fitness (CRF) were also measured via MetS z-score, HOMA-IR, dual-energy X-ray absorptiometry, and indirect calorimetry (maximal exercise test), respectively.Results: The median (IQR) IL-22% changes from pre- to post-intervention in the MICT, 4HIIT, and 1HIIT groups were − 17% (− 43.0% to 31.3%), +16.5% (− 18.9% to 154.9%), and +15.9% (− 28.7% to 46.1%), respectively. Although there were no significant between-group differences in IL-22 concentration change, there was a medium-to-large group × time interaction effect [F(2,35)=2.08, p=0.14, η2=0.14].Conclusion: Although there was no statistically significant between-group difference in IL-22 change, the study suggests that different exercise intensities may have opposing effects on IL-22 concentration in individuals with MetS.",

keywords = "high-intensity interval training, IL-22, inflammation, cardiovascular disease, metabolic syndrome, cytokine, Cytokine, High-intensity interval training, Cardiovascular disease, Inflammation, Metabolic syndrome",

author = "Joyce Ramos and Lance Dalleck and Rebecca Stennett and Mielke, {Gregore Iven} and Keating, {Shelley E.} and Lydia Murray and Sumaira Hasnain and Robert Fassett and Michael McGuckin and Ilaria Croci and Jeff Coombes",

note = "This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution–Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing thework you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Forpermission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).",

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month = jul,

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doi = "10.2147/DMSO.S251567",

language = "English",

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journal = "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy",

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Ramos, J, Dalleck, L, Stennett, R, Mielke, GI, Keating, SE, Murray, L, Hasnain, S, Fassett, R, McGuckin, M, Croci, I & Coombes, J 2020, 'Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial', Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, vol. 13, pp. 2443-2453. https://doi.org/10.2147/DMSO.S251567

Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome : A Randomized Trial. / Ramos, Joyce; Dalleck, Lance; Stennett, Rebecca et al.

In: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol. 13, 09.07.2020, p. 2443-2453.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome

T2 - A Randomized Trial

AU - Ramos, Joyce

AU - Dalleck, Lance

AU - Stennett, Rebecca

AU - Mielke, Gregore Iven

AU - Keating, Shelley E.

AU - Murray, Lydia

AU - Hasnain, Sumaira

AU - Fassett, Robert

AU - McGuckin, Michael

AU - Croci, Ilaria

AU - Coombes, Jeff

N1 - This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution–Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing thework you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Forpermission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PY - 2020/7/9

Y1 - 2020/7/9

N2 - Introduction: IL-22 may have a role in the alleviation of the metabolic syndrome (MetS) via protection of pancreatic beta and endothelial cells from oxidative and lipid-induced damage. We aimed to investigate the effects of moderate-intensity continuous training (MICT) and different volumes of high-intensity interval training (HIIT) on changes in circulating IL-22.Methods: This was a sub-study of the “Exercise in the prevention of Metabolic Syndrome” (EX-MET) a multi-center, randomized trial. This study used data collected at the Brisbane site. Thirty-nine individuals with MetS were randomized to one of three 16-wk interventions: 1) MICT (n=10, 30min at 60– 70% HR peak, 5x/wk); 2) 4HIIT (n=13, 4x4min at 85– 95% HR peak, interspersed with 3min of active recovery at 50– 70% HR peak, 3x/wk); or 3) 1HIIT (n=16, 1x4min at 85– 95% HR peak, 3x/wk). Serum IL-22 concentration was measured following a 12-hr fast via an enzyme linked immunosorbent assay, before and after the intervention. MetS severity, insulin resistance (IR), visceral adipose tissue (VAT), and cardiorespiratory fitness (CRF) were also measured via MetS z-score, HOMA-IR, dual-energy X-ray absorptiometry, and indirect calorimetry (maximal exercise test), respectively.Results: The median (IQR) IL-22% changes from pre- to post-intervention in the MICT, 4HIIT, and 1HIIT groups were − 17% (− 43.0% to 31.3%), +16.5% (− 18.9% to 154.9%), and +15.9% (− 28.7% to 46.1%), respectively. Although there were no significant between-group differences in IL-22 concentration change, there was a medium-to-large group × time interaction effect [F(2,35)=2.08, p=0.14, η2=0.14].Conclusion: Although there was no statistically significant between-group difference in IL-22 change, the study suggests that different exercise intensities may have opposing effects on IL-22 concentration in individuals with MetS.

AB - Introduction: IL-22 may have a role in the alleviation of the metabolic syndrome (MetS) via protection of pancreatic beta and endothelial cells from oxidative and lipid-induced damage. We aimed to investigate the effects of moderate-intensity continuous training (MICT) and different volumes of high-intensity interval training (HIIT) on changes in circulating IL-22.Methods: This was a sub-study of the “Exercise in the prevention of Metabolic Syndrome” (EX-MET) a multi-center, randomized trial. This study used data collected at the Brisbane site. Thirty-nine individuals with MetS were randomized to one of three 16-wk interventions: 1) MICT (n=10, 30min at 60– 70% HR peak, 5x/wk); 2) 4HIIT (n=13, 4x4min at 85– 95% HR peak, interspersed with 3min of active recovery at 50– 70% HR peak, 3x/wk); or 3) 1HIIT (n=16, 1x4min at 85– 95% HR peak, 3x/wk). Serum IL-22 concentration was measured following a 12-hr fast via an enzyme linked immunosorbent assay, before and after the intervention. MetS severity, insulin resistance (IR), visceral adipose tissue (VAT), and cardiorespiratory fitness (CRF) were also measured via MetS z-score, HOMA-IR, dual-energy X-ray absorptiometry, and indirect calorimetry (maximal exercise test), respectively.Results: The median (IQR) IL-22% changes from pre- to post-intervention in the MICT, 4HIIT, and 1HIIT groups were − 17% (− 43.0% to 31.3%), +16.5% (− 18.9% to 154.9%), and +15.9% (− 28.7% to 46.1%), respectively. Although there were no significant between-group differences in IL-22 concentration change, there was a medium-to-large group × time interaction effect [F(2,35)=2.08, p=0.14, η2=0.14].Conclusion: Although there was no statistically significant between-group difference in IL-22 change, the study suggests that different exercise intensities may have opposing effects on IL-22 concentration in individuals with MetS.

KW - high-intensity interval training

KW - IL-22

KW - inflammation

KW - cardiovascular disease

KW - metabolic syndrome

KW - cytokine

KW - Cytokine

KW - High-intensity interval training

KW - Cardiovascular disease

KW - Inflammation

KW - Metabolic syndrome

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DO - 10.2147/DMSO.S251567

M3 - Article

SN - 1178-7007

VL - 13

SP - 2443

EP - 2453

JO - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

JF - Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

ER -

Effect of Different Volumes of Interval Training and Continuous Exercise on Interleukin-22 in Adults with Metabolic Syndrome: A Randomized Trial

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