Effect of Folic Acid Supplementation on Plasma Zinc Concentrations of Young Women

Timothy J. Green; C. Murray Skeaff; Susan J. Whiting; Rosalind S. Gibson

doi:10.1016/S0899-9007(02)01100-0

Effect of Folic Acid Supplementation on Plasma Zinc Concentrations of Young Women

Timothy J. Green, C. Murray Skeaff, Susan J. Whiting, Rosalind S. Gibson

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

OBJECTIVE: Women of reproductive age are advised to consume supplements or fortified foods containing at least 400 μg/d folic acid for the prevention of neural tubes defects. Concerns exist about the adverse effects of folic acid on zinc status. METHODS: Seventy-eight women (18 to 49 y) were assigned for 12-wk to receive either a placebo or a 400 μg/d folic acid supplement. RESULTS: At 12-wk mean (95% CI) red cell folate increased by 431 (350-511) nmol/L in the supplemented group relative to placebo (P < 0.001) but there was no change in plasma zinc in either group (P = 0.213). CONCLUSIONS: Folic acid supplementation does not reduce plasma zinc concentrations in women of childbearing age.

Original language	English
Pages (from-to)	522-523
Number of pages	2
Journal	Nutrition
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/S0899-9007(02)01100-0
Publication status	Published - 1 Jun 2003
Externally published	Yes

Keywords

Folic acid
Plasma zinc
Red cell folate
Supplements
Women
Zinc

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title = "Effect of Folic Acid Supplementation on Plasma Zinc Concentrations of Young Women",

abstract = "OBJECTIVE: Women of reproductive age are advised to consume supplements or fortified foods containing at least 400 μg/d folic acid for the prevention of neural tubes defects. Concerns exist about the adverse effects of folic acid on zinc status. METHODS: Seventy-eight women (18 to 49 y) were assigned for 12-wk to receive either a placebo or a 400 μg/d folic acid supplement. RESULTS: At 12-wk mean (95% CI) red cell folate increased by 431 (350-511) nmol/L in the supplemented group relative to placebo (P < 0.001) but there was no change in plasma zinc in either group (P = 0.213). CONCLUSIONS: Folic acid supplementation does not reduce plasma zinc concentrations in women of childbearing age.",

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T1 - Effect of Folic Acid Supplementation on Plasma Zinc Concentrations of Young Women

AU - Green, Timothy J.

AU - Skeaff, C. Murray

AU - Whiting, Susan J.

AU - Gibson, Rosalind S.

PY - 2003/6/1

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N2 - OBJECTIVE: Women of reproductive age are advised to consume supplements or fortified foods containing at least 400 μg/d folic acid for the prevention of neural tubes defects. Concerns exist about the adverse effects of folic acid on zinc status. METHODS: Seventy-eight women (18 to 49 y) were assigned for 12-wk to receive either a placebo or a 400 μg/d folic acid supplement. RESULTS: At 12-wk mean (95% CI) red cell folate increased by 431 (350-511) nmol/L in the supplemented group relative to placebo (P < 0.001) but there was no change in plasma zinc in either group (P = 0.213). CONCLUSIONS: Folic acid supplementation does not reduce plasma zinc concentrations in women of childbearing age.

AB - OBJECTIVE: Women of reproductive age are advised to consume supplements or fortified foods containing at least 400 μg/d folic acid for the prevention of neural tubes defects. Concerns exist about the adverse effects of folic acid on zinc status. METHODS: Seventy-eight women (18 to 49 y) were assigned for 12-wk to receive either a placebo or a 400 μg/d folic acid supplement. RESULTS: At 12-wk mean (95% CI) red cell folate increased by 431 (350-511) nmol/L in the supplemented group relative to placebo (P < 0.001) but there was no change in plasma zinc in either group (P = 0.213). CONCLUSIONS: Folic acid supplementation does not reduce plasma zinc concentrations in women of childbearing age.

KW - Folic acid

KW - Plasma zinc

KW - Red cell folate

KW - Supplements

KW - Women

KW - Zinc

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Effect of Folic Acid Supplementation on Plasma Zinc Concentrations of Young Women

Abstract

Keywords

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