Effect of Heparin Surface Modification of Polymethylmethacrylate Intraocular Lenses on Signs of Postoperative Inflammation after Extracapsular Cataract Extraction: One-year Results of a Double-masked Multicenter Study

Dott Marco Borgioli, Douglas J. Coster, Richard F.T. Fan, John Henderson, Karl W. Jacobi, Graham R. Kirkby, Yoon Kee Lai, José L. Menezo, Michel Montard, Jürgen Strobel, Josef Wollensak

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49 Citations (Scopus)

Abstract

Purpose: A heparin surface modified posterior chamber intraocular lens (IOL) was compared with a conventional polymethylmethacrylate (PMMA) IOL regarding postoperative complications caused by inflammation. Methods: Five hundred twenty-four patients from 10 different centers were included in a parallel group, double-masked, multicenter study. Results: The cumulative number of patients with inflammatory cellular deposits on their IOLs during the first postoperative year differed significantly in favor of the heparin surface modified group, with 29.8% of the patients having cellular deposits compared with 48.8% of patients in the control group. Cellular deposits were observed most frequently at 3 months after surgery, and the difference between the groups was most pronounced and statistically significant at this time. The same results were seen at 1 year, but the difference was not significant. The number of cellular deposits per patient, however, was significantly lower in the heparin surface modified group at 1 year. Cumulatively, there were significantly more patients with posterior -synechiae in the PMMA group than in the heparin surface modified group during the 1-year follow-up. Complications were few and comparable between the groups. Conclusion: The results of this study indicate that heparin surface modification reduces the inflammatory response to PMMA IOLs.

Original languageEnglish
Pages (from-to)1248-1255
Number of pages8
JournalOphthalmology
Volume99
Issue number8
DOIs
Publication statusPublished - 1 Jan 1992
Externally publishedYes

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