Dear Editor. Sleep disturbances are an early feature of Huntington disease(HD), which worsen as the disease progresses. Studies have documented increased sleep fragmentation, decreased rapid eye-movement (REM) sleep, reduced sleep efficiency, insomnia and an increase in periodic leg movements (PLMs) in individuals with HD [1,2]. Disturbances in sleep are thought to exacerbate cognitive impairments and may hasten subcortical neurodegeneration [3,4]. Hence, management of sleep disturbances in individuals with HD is imperative...
- Huntington disease
- sleep disorders
- sleep fragmentation
- periodic leg movements (PLMs)