Effect of nerve activity on transport of nerve growth factor and dopamine β-hydroxylase antibodies in sympathetic neurones

G. Lees, I. Chubb, C. Freeman, L. Geffen, R. Rush

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    The effect of nerve activity on the uptake and retrograde transport of nerve growth factor (NGF) and dopamine β-hydroxylase (DBH) antibodies was studied by injecting 125I-labelled NGF and anti-DBH into the anterior eye chamber of guinea-pigs. Decentralization of the ipsilateral superior cervical ganglion (SCG) had no significant effect on the retrograde transport of either NGF or anti-DBH. Phenoxybenzamine produced a 50% increase in anti-DBH but not NGF accumulation and this effect was prevented by prior decentralization. This demonstrates that NGF is taken up independently of the retrieval of synaptic vesicle components.

    Original languageEnglish
    Pages (from-to)186-189
    Number of pages4
    JournalBrain Research
    Volume214
    Issue number1
    DOIs
    Publication statusPublished - 9 Jun 1981

    Keywords

    • dopamine β-hydroxylase antibody
    • nerve activity
    • nerve growth factor
    • sympathetic neuron

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